2. Metabolic Enzyme/Protease
  3. Glycosidase
  4. α-Glucosidase-IN-11

α-Glucosidase-IN-11 is a highly permeable competitive α-glucosidase inhibitor with the IC50 value of 0.56 μM. α-Glucosidase-IN-11 binds to Trp residues in α-glucosidase and regulates protein folding. α-Glucosidase-IN-11 can be used to regulate blood glucose levels.

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α-Glucosidase-IN-11

α-Glucosidase-IN-11 Estructura química

No. CAS : 2411744-76-6

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5 mg Obtener un presupuesto 3 - 5 weeks 2 - 4 weeks 4 - 6 weeks 2 - 4 weeks
10 mg Obtener un presupuesto 3 - 5 weeks 2 - 4 weeks 4 - 6 weeks 2 - 4 weeks
25 mg Obtener un presupuesto 3 - 5 weeks 2 - 4 weeks 4 - 6 weeks 2 - 4 weeks
50 mg Obtener un presupuesto 3 - 5 weeks 2 - 4 weeks 4 - 6 weeks 2 - 4 weeks
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200 mg   Obtener un presupuesto  
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α-Glucosidase-IN-11 Related Antibodies

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Descripciòn

α-Glucosidase-IN-11 is a highly permeable competitive α-glucosidase inhibitor with the IC50 value of 0.56 μM. α-Glucosidase-IN-11 binds to Trp residues in α-glucosidase and regulates protein folding. α-Glucosidase-IN-11 can be used to regulate blood glucose levels[1].

In Vitro

α-Glucosidase-IN-11 (compound 3k) inhibits α-glucosidase, α-fucosidase and α-mannosidase with the IC50 value of 0.56 μM, 30.4 μM and 41.2 μM, respectively[1].
α-Glucosidase-IN-11 (compound 3k) ( 0.1-100 μM, 24 hours) can induce β-cell proliferation at lower concentration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Glucosidase-IN-11 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: BRIN-BD11 cells (rat beta cell line)
Concentration: 0.1-100 μM
Incubation Time: 24 hours
Result: Showed cell proliferation at low concentration of 1 μM and minor cytotoxic effect at higher concentration greater than 10 μM.
In Vivo

α-Glucosidase-IN-11 (compound 3k) (gastric gavage, 60 mg/kg, everyday, 4 weeks) can improve blood glucose levels during fasting[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats (250e320g)[1]
Dosage: 60 mg/kg
Administration: Gastric gavage; everyday; 4 weeks
Result: Caused a significant drop in fasting blood glucose during the first and second weeks but did not cause a decrease in non-fasting blood glucose for up to four weeks.
Peso molecular

420.41

Fòrmula

C23H20N2O6
No. CAS
SMILES

O=C(OCC)C1=CC=C(N2C(CO)=CC=C2/C=C3OC(C4=C\3C=C(C)NC4=O)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
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α-Glucosidase-IN-11 Related Classifications

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Keywords:

α-Glucosidase-IN-112411744-76-6Glycosidaseα-glucosidase inhibitorblood glucosediabeticInhibitorinhibitorinhibit

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Nombre del producto:
α-Glucosidase-IN-11
Cat. No.:
HY-150560
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