2. Metabolic Enzyme/Protease
  3. Glycosidase
  4. α-Glucosidase-IN-20

α-Glucosidase-IN-20 (Compound 3B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 3.01 μM. α-Glucosidase-IN-20 shows anti-diabetic activity.

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α-Glucosidase-IN-20

α-Glucosidase-IN-20 Chemische Struktur

CAS. Nr. : 420809-56-9

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Beschreibung

α-Glucosidase-IN-20 (Compound 3B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 3.01 μM. α-Glucosidase-IN-20 shows anti-diabetic activity[1].

In Vivo

α-Glucosidase-IN-20 (Compound 3B; 10 and 20 mg/kg; p.o.; daily, for 4 weeks) has anti-diabetic activity in Streptozocin (HY-13753)-induced diabetic rats[1].
α-Glucosidase-IN-20 (10 and 20 mg/kg; p.o.; once) significantly decreases the serum glucose level after the administration of glucose (3 g/kg, oral) in rats[1].
α-Glucosidase-IN-20 (2000 mg/kg; p.o.; daily, for 2 weeks) demonstrates no mortality in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar albino rats (170-200 g), Streptozotocin-induced diabetes model[1]
Dosage: 10 and 20 mg/kg
Administration: Oral administration; daily, for 4 weeks
Result: Decreased the level of blood glucose, reversed Streptozocin-induced body weight loss. Showed antihyperlipidemic effects on Streptozotocin-induced diabetes, reduced to a significant level of serum biomarkers.
Molekulargewicht

359.48

Formel

C23H21NOS
CAS. Nr.
SMILES

COC1=CC=C(C=C1)C2CC(C3=CC=C(C=C3)C)=NC4=C(S2)C=CC=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

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α-Glucosidase-IN-20 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Glucosidase-IN-20420809-56-9Glycosidaseanti-diabeticblood glucoseanti-hyperlipidemicdiabetesInhibitorinhibitorinhibit

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