1,2-Cyclohexylenedinitrilotetraacetic acid (Synonyms: CDTA)

Cat. No.: HY-W102714 Purity: 99.91%: Data Sheet
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1,2-Cyclohexylenedinitrilotetraacetic acid (CDTA) is a chelating agent. 1,2-Cyclohexylenedinitrilotetraacetic acid has an ability to remove manganese from brain and liver (in vivo) and their sub-cellular fractions (in vitro), of rats pretreated with manganese sulphate.

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1,2-Cyclohexylenedinitrilotetraacetic acid 화학구조

CAS No. : 482-54-2

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
100 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	견적 받기
10 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

Other Forms of 1,2-Cyclohexylenedinitrilotetraacetic acid:

1,2-Cyclohexylenedinitrilotetraacetic acid (Standard) 견적 받기

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Biological Activity
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References
고객리뷰

제품 설명

In Vitro

1,2-Cyclohexylenedinitrilotetraacetic acid is an analogue of EDTA, with the vinyl group replaced by a cyclohexenyl group and the two aminoacetic acid groups in a trans configuration. 1,2-Cyclohexylenedinitrilotetraacetic acid exhibits stronger lipophilicity and pre-organization ability, and forms more stable complex with metal ions^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

1,2-Cyclohexylenedinitrilotetraacetic acid (36 mg/kg, ip, once a day for two days) alleviates manganese-induced acute neurotoxicity in Sprague-Dawley rats models^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Manganese-induced acute neurotoxicity in Sprague-Dawley rats models^[3]
Dosage:	36 mg/kg
Administration:	ip, once a day for two days
Result:	Reduced the manganese ion concentration in the brain tissue, prevented the occurance of pathological changes such as Alzheimer's type II astrocyte proliferation.

분자량

346.33

화학식

C₁₄H₂₂N₂O₈

CAS No.

482-54-2

Appearance

Solid

Color

White to off-white

SMILES

C1CCC(C(C1)N(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 5.71 mg/mL (16.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8874 mL	14.4371 mL	28.8742 mL
5 mM	0.5775 mL	2.8874 mL	5.7748 mL
10 mM	0.2887 mL	1.4437 mL	2.8874 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.91%

Select Batch:

Data Sheet (277 KB) SDS (394 KB)

COA (254 KB) HNMR (261 KB) RP-HPLC (214 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Tandon SK, et al. Removal of manganese by chelating agents from brain and liver of manganese treated rats: as in vitro and an in vivo study. Toxicology. 1975 Nov;5(2):237-41. [Content Brief]

[2]. Sun Y, et al., Synthesis and characterization of racemic mixture and meso isomers of bis(trans-2-aminocyclohexyl)aminepentaacetic acid and the stabilities of their Gd(III) complexes. Inorg Chem. 2000 Apr 3;39(7):1480-6. [Content Brief]

[3]. Hazell AS, et al., Alzheimer type II astrocytic changes following sub-acute exposure to manganese and its prevention by antioxidant treatment. Neurosci Lett. 2006 Apr 3;396(3):167-71. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8874 mL	14.4371 mL	28.8742 mL	72.1855 mL
	5 mM	0.5775 mL	2.8874 mL	5.7748 mL	14.4371 mL
	10 mM	0.2887 mL	1.4437 mL	2.8874 mL	7.2185 mL
	15 mM	0.1925 mL	0.9625 mL	1.9249 mL	4.8124 mL

1,2-Cyclohexylenedinitrilotetraacetic acid Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,2-Cyclohexylenedinitrilotetraacetic acid482-54-2CDTABiochemical Assay ReagentsSprague-Dawley ratEDTAInhibitorinhibitorinhibit

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1,2-Cyclohexylenedinitrilotetraacetic acid (Synonyms: CDTA)

Other Forms of 1,2-Cyclohexylenedinitrilotetraacetic acid:

1,2-Cyclohexylenedinitrilotetraacetic acid Related Antibodies

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•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

1,2-Cyclohexylenedinitrilotetraacetic acid Related Antibodies

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