1. Membrane Transporter/Ion Channel
    Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
  2. Potassium Channel
    NF-κB
    NO Synthase
    Reactive Oxygen Species
    NADPH Oxidase
    Endogenous Metabolite
  3. 20-HETE

20-HETE (Synonyms: 20-hydroxy Arachidonic Acid)

製品番号: HY-15598 純度: >95.0%
取扱説明書

20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor. 20-HETE is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE constricts smooth muscles, stimulates smooth muscle proliferation and migration. 20-HETE increases NADPH oxidase, ROS, and NF-κB activity. 20-HETE also inhibits endothelial NO synthase and inhibits apoptosis of pulmonary artery smooth muscle cells.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用としては使用しないように、十分ご注意ください。

20-HETE 構造式

20-HETE 構造式

CAS 番号 : 79551-86-3

容量 価格(税別) 在庫状況 数量
2 mg USD 168 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 278 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 426 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 1440 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 2520 在庫あり
Estimated Time of Arrival: December 31
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

NF-κB アイソフォーム固有の製品をすべて表示:

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor. 20-HETE is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE constricts smooth muscles, stimulates smooth muscle proliferation and migration. 20-HETE increases NADPH oxidase, ROS, and NF-κB activity. 20-HETE also inhibits endothelial NO synthase and inhibits apoptosis of pulmonary artery smooth muscle cells[1][2].

IC50 & Target

Human Endogenous Metabolite

 

体外実験

Addition of 20-HETE to the bath (1-100 nM), reduces the frequency of opening of the large-conductance Ca2+-activated K+ channel recorded using cell-attached patches on vascular smooth muscle cells (VSM)[1].
20-HETE (1-1000 nM) reduces the diameter of isolated perfused small renal arteries of the rat by approximately 15% tetraethylammonium (1 mM) blocked the vasoconstrictor response to 20-HETE (100 nM)[1].
20-HETE induces the phosphorylation of ERK1/2, a MAPK that plays a pivotal role in the proliferation induced by the activation of receptor tyrosine kinases and G protein-coupled receptors. 20-HETE promotes platelet-derived growth factor-stimulated vascular smooth muscle cell migration via pathways that involve MEK and phosphatidylinositol 3-kinase activation[2].

体内実験

In Sprague-Dawley rats, administration of the 20-HETE inhibitor HET0016 or the 20-HETE antagonist 20-HEDE preventes DHT-induced increases in blood pressure as well as abrogates DHT-induced increases in the media-to-lumen ratio (M/L), media thickness, and collagen IV deposition in renal interlobar arteries. 20-HETE contributes to DHT-induced vascular remodeling independent of blood pressure elevation[2].
In Cyp4a14-/- mice, which display androgen-driven and 20-HETE-dependent hypertension, treatment with the 20-HETE antagonist abolishes remodeling of renal resistance arteries measured as media thickness and M/L. 20-HETE is a key regulator of microvascular remodeling in hypertension; its effect is independent of blood pressure elevation and androgen levels[2].

分子量

320.47

分子式

C₂₀H₃₂O₃

CAS 番号

79551-86-3

SMILES

O=C(O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCCO

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, protect from light, stored under argon

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under argon)

溶剤 & 溶解度
体外: 

Ethanol : 6.67 mg/mL (20.81 mM; Need ultrasonic)

DMSO : ≥ 3.2 mg/mL (9.99 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1204 mL 15.6021 mL 31.2042 mL
5 mM 0.6241 mL 3.1204 mL 6.2408 mL
10 mM 0.3120 mL 1.5602 mL 3.1204 mL
*Please refer to the solubility information to select the appropriate solvent.
参考文献
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • モル濃度カルキュレーター

  • 希釈カルキュレーター

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

20-HETE20-hydroxy Arachidonic AcidPotassium ChannelNF-κBNO SynthaseReactive Oxygen SpeciesNADPH OxidaseEndogenous MetaboliteKcsANuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSNOXVasoconstrictorCa2+-activatedVSMCYP450metabolitehypertensionNF-kBinflammatoryapoptosisROSInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

 

タイトル

お名前 *

 

PC 用メールアドレス *

電話番号 *

 

勤務先/学校名 *

国会或いは地域 *

 

カスタマ需要量 *

必ず会社名を記載ください。個人への返信は行いません。

メッセージ

バルクお問い合わせ

Inquiry Information

製品名:
20-HETE
製品番号:
HY-15598
数量:
MCE 日本正規代理店: