2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. CYP4A11/CYP4F2-IN-1

CYP4A11/CYP4F2-IN-1 is a potent dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50s of 19 nM and 17 nM, respectively. CYP4A11/CYP4F2-IN-1 has potential for the research of renal diseases.

For research use only. We do not sell to patients.

CYP4A11/CYP4F2-IN-1 Chemical Structure

CYP4A11/CYP4F2-IN-1 Chemical Structure

CAS No. : 502654-40-2

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10 mg USD 380 In-stock
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Based on 1 publication(s) in Google Scholar

CYP4A11/CYP4F2-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP3A4 CYP17A1

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Description

CYP4A11/CYP4F2-IN-1 is a potent dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50s of 19 nM and 17 nM, respectively. CYP4A11/CYP4F2-IN-1 has potential for the research of renal diseases[1].

IC50 & Target[1]

CYP4A11

19 nM (IC50)

CYP4F2

17 nM (IC50)

In Vitro

CYP4A11/CYP4F2-IN-1 (compound 2) inhibits 20-Hydroxyeicosatetraenoic acid (20-HETE) production from arachidonic acid in human renal microsomes, with an IC50 of 4.2 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CYP4A11/CYP4F2-IN-1 Related Antibodies
Molecular Weight

285.36

Formula

C15H15N3OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=C(SC=N1)CCOC2=CC=C(C=C2)C3=CC=NN3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (438.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5043 mL 17.5217 mL 35.0435 mL
5 mM 0.7009 mL 3.5043 mL 7.0087 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5043 mL 17.5217 mL 35.0435 mL 87.6086 mL
5 mM 0.7009 mL 3.5043 mL 7.0087 mL 17.5217 mL
10 mM 0.3504 mL 1.7522 mL 3.5043 mL 8.7609 mL
15 mM 0.2336 mL 1.1681 mL 2.3362 mL 5.8406 mL
20 mM 0.1752 mL 0.8761 mL 1.7522 mL 4.3804 mL
25 mM 0.1402 mL 0.7009 mL 1.4017 mL 3.5043 mL
30 mM 0.1168 mL 0.5841 mL 1.1681 mL 2.9203 mL
40 mM 0.0876 mL 0.4380 mL 0.8761 mL 2.1902 mL
50 mM 0.0701 mL 0.3504 mL 0.7009 mL 1.7522 mL
60 mM 0.0584 mL 0.2920 mL 0.5841 mL 1.4601 mL
80 mM 0.0438 mL 0.2190 mL 0.4380 mL 1.0951 mL
100 mM 0.0350 mL 0.1752 mL 0.3504 mL 0.8761 mL
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CYP4A11/CYP4F2-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP4A11/CYP4F2-IN-1502654-40-2Cytochrome P450CYPsrenal diseases20-HETEInhibitorinhibitorinhibit

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