22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (compound 6n) is an antibacterial pleuromutilin derivative against Gram-positive pathogens (GPPs) and Mycoplasma pneumoniae.
For research use only. We do not sell to patients.
- CAS No.: 2780409-77-8
- Formula: C30H42N2O6
- Molecular Weight:526.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
>10 μM
Compound: 6n
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Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
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[PMID: 35220163] |
| HGC-27 | IC50 |
>10 μM
Compound: 6n
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Cytotoxicity against human HGC-27 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human HGC-27 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
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[PMID: 35220163] |
| HT-29 | IC50 |
>10 μM
Compound: 6n
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Cytotoxicity against human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
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[PMID: 35220163] |
| MCF7 | IC50 |
>10 μM
Compound: 6n
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Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
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[PMID: 35220163] |
| U-87MG ATCC | IC50 |
>10 μM
Compound: 6n
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Cytotoxicity against human U87 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human U87 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
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[PMID: 35220163] |
In Vitro
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (compound 6n) (0.0625 -128 µg/mL, 8 h) shows antibacterial activity with MICs of 0.0625, 0.5, 8, 0.125, 0.0625, and 0.5 µg/mL against MSSA, MRSA, E.faecium, M.pneumonia (ATCC15331), M.pneumonia (ATCC29342), and M.pneumonia (resistant strain, clinically isolated strain), respectively[1].
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (0-10 µg/mL, 72 h) shows low cytotoxicity in human cancer cells[1].
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin exhibits good ADMET properties with high LogS, attractive ALogP, low PPB, non-Ames toxic, and non-carcinogenic[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Five human cancer cell lines (HeG2, U87, HGC27, HT29 and MCF2)
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Concentration:0-10 µg/mL
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Incubation Time:72 h
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Result:Showed low cytotoxicity ((IC50>10 μmol/L).
Chemical Information
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CAS No. 2780409-77-8
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Molecular Weight 526.66
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Formula C30H42N2O6
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SMILES
C[C@]1(C[C@H]([C@@]([C@H](C)CC2)(C)[C@H](C(CC3)=O)[C@@]23[C@H]([C@@H]1O)C)OC(CNC(NC4=CC=C(C=C4)OC)=O)=O)C=C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin Related Classifications
HY-146756 Related Classifications
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