22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin

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22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (compound 6n) is an antibacterial pleuromutilin derivative against Gram-positive pathogens (GPPs) and Mycoplasma pneumoniae.

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22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin 화학구조

CAS No. : 2780409-77-8

사이즈		재고
MOQ		Minimum order quantity
50 mg		견적 받기
100 mg		견적 받기
250 mg		견적 받기
Other size		견적 받기

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (compound 6n) is an antibacterial pleuromutilin derivative against Gram-positive pathogens (GPPs) and Mycoplasma pneumoniae^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	>10 3 Compound: 6n	Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 35220163]
HGC-27	IC₅₀	> 10 3 Compound: 6n	Cytotoxicity against human HGC-27 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human HGC-27 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 35220163]
HT-29	IC₅₀	> 10 3 Compound: 6n	Cytotoxicity against human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 35220163]
HGC-27	IC₅₀	>10 3 Compound: 6n	Cytotoxicity against human HGC-27 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human HGC-27 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 35220163]
HepG2	IC₅₀	> 10 3 Compound: 6n	Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 35220163]
HT-29	IC₅₀	>10 3 Compound: 6n	Cytotoxicity against human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 35220163]
MCF7	IC₅₀	> 10 3 Compound: 6n	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 35220163]
MCF7	IC₅₀	>10 3 Compound: 6n	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 35220163]
U-87MG ATCC	IC₅₀	> 10 3 Compound: 6n	Cytotoxicity against human U87 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human U87 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 35220163]
U-87MG ATCC	IC₅₀	>10 3 Compound: 6n	Cytotoxicity against human U87 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human U87 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 35220163]

In Vitro

22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (compound 6n) (0.0625 -128 µg/mL, 8 h) shows antibacterial activity with MICs of 0.0625, 0.5, 8, 0.125, 0.0625, and 0.5 µg/mL against MSSA, MRSA, E.faecium, M.pneumonia (ATCC15331), M.pneumonia (ATCC29342), and M.pneumonia (resistant strain, clinically isolated strain), respectively^[1].
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (0-10 µg/mL, 72 h) shows low cytotoxicity in human cancer cells^[1].
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin exhibits good ADMET properties with high LogS, attractive ALogP, low PPB, non-Ames toxic, and non-carcinogenic^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	Five human cancer cell lines (HeG2, U87, HGC27, HT29 and MCF2)
Concentration:	0-10 µg/mL
Incubation Time:	72 h
Result:	Showed low cytotoxicity ((IC₅₀>10 μmol/L).

분자량

526.66

화학식

C₃₀H₄₂N₂O₆

CAS No.

2780409-77-8

SMILES

C[C@]1(C[C@H]([C@@]([C@H](C)CC2)(C)[C@H](C(CC3)=O)[C@@]23[C@H]([C@@H]1O)C)OC(CNC(NC4=CC=C(C=C4)OC)=O)=O)C=C

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Guangxu Wu, et al. Design, synthesis and antibacterial evaluation of pleuromutilin derivatives. Bioorg Med Chem. 2022 Apr 1;59:116676. [Content Brief]