(3β,4β,17β)-17-(2-Pyridinylmethyl)androst-5-ene-3,4,17-triol

Cat. No.: HY-161701: Data Sheet Handling Instructions
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(3β,4β,17β)-17-(2-Pyridinylmethyl)androst-5-ene-3,4,17-triol is an androstane derivative with anticancer activity.

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(3β,4β,17β)-17-(2-Pyridinylmethyl)androst-5-ene-3,4,17-triol Chemical Structure

CAS No. : 1393651-00-7

Size	Stock	Quantity
1 mg	Get quote 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Biological Activity
Purity & Documentation
References
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Description

(3β,4β,17β)-17-(2-Pyridinylmethyl)androst-5-ene-3,4,17-triol is an androstane derivative with anticancer activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 100 μM Compound: 1	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 26494582]
HT-29	IC₅₀	5.29 μM Compound: 1	Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 26494582]
HT-29	IC₅₀	8 μM Compound: 6	Cytotoxicity against human HT-29 cells after 1 hr by SRB assay Cytotoxicity against human HT-29 cells after 1 hr by SRB assay	[PMID: 22770744]
HeLa	IC₅₀	23.97 μM Compound: 1	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 26494582]
HeLa	IC₅₀	26.6 μM Compound: 6	Cytotoxicity against human HeLa cells after 1 hr by SRB assay Cytotoxicity against human HeLa cells after 1 hr by SRB assay	[PMID: 22770744]
K562	IC₅₀	> 100 μM Compound: 1	Antiproliferative activity against human K562 cells after 48 hrs by MTT assay Antiproliferative activity against human K562 cells after 48 hrs by MTT assay	[PMID: 26494582]
MCF7	IC₅₀	> 100 μM Compound: 1	Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 26494582]
MCF7	IC₅₀	> 100 μM Compound: 1	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 26494582]
MCF7	IC₅₀	> 100 μM Compound: 1	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 26494582]
MCF7	IC₅₀	> 100 μM Compound: 6	Cytotoxicity against ER-positive human MCF7 cells after 1 hr by SRB assay Cytotoxicity against ER-positive human MCF7 cells after 1 hr by SRB assay	[PMID: 22770744]
MDA-MB-231	IC₅₀	2.72 μM Compound: 1	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 26494582]
MDA-MB-231	IC₅₀	6.43 μM Compound: 1	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 26494582]
MDA-MB-231	IC₅₀	9 μM Compound: 6	Cytotoxicity against ER-negative human MDA-MB-231 cells after 1 hr by SRB assay Cytotoxicity against ER-negative human MDA-MB-231 cells after 1 hr by SRB assay	[PMID: 22770744]
MDA-MB-231	IC₅₀	> 100 μM Compound: 1	Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay	[PMID: 26494582]
MRC5	IC₅₀	> 100 μM Compound: 1	Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay	[PMID: 26494582]
MRC5	IC₅₀	> 100 μM Compound: 6	Cytotoxicity against human MRC5 cells after 1 hr by SRB assay Cytotoxicity against human MRC5 cells after 1 hr by SRB assay	[PMID: 22770744]
PC-3	IC₅₀	41.29 μM Compound: 1	Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay	[PMID: 26494582]
PC-3	IC₅₀	52.1 μM Compound: 6	Cytotoxicity against AR-negative human PC3 cells after 1 hr by SRB assay Cytotoxicity against AR-negative human PC3 cells after 1 hr by SRB assay	[PMID: 22770744]

Molecular Weight

397.55

Formula

C₂₅H₃₅NO₃

CAS No.

1393651-00-7

SMILES

C[C@@]12[C@@](O)(CC[C@@]1([H])[C@@]3([H])[C@]([C@@]4(C([C@H]([C@H](CC4)O)O)=CC3)C)([H])CC2)CC5=CC=CC=N5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Šestić TL, et al. In silico ADMET analysis of the A-, B- and D-modified androstane derivatives with potential anticancer effects. Steroids. 2023 Jan;189:109147. [Content Brief]