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  4. 4,7-Dimethoxy-5-methyl-1,3-benzodioxole

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4,7-Dimethoxy-5-methyl-1,3-benzodioxole

4,7-Dimethoxy-5-methyl-1,3-benzodioxole Chemical Structure

CAS No. : 165816-66-0

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4,7-Dimethoxy-5-methyl-1,3-benzodioxole Related Antibodies

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In Vitro

4,7-Dimethoxy-5-methyl-1,3-benzodioxole Related Antibodies

Cell Viability Assay[1]

Cell Line: murine macrophage RAW264.7 cells (with LPS stimulation)
Concentration: 62.5 μM, 125 μM, 250 μM, 500 μM
Incubation Time: 24 h
Result: Did not reduce cell viability compared to the untreated control group.

ELISA Assay[1]

Cell Line: murine macrophage RAW264.7 cells (with LPS stimulation)
Concentration: 62.5 μM, 125 μM, 250 μM, 500 μM
Incubation Time: 24 h
Result: Slightly inhibited LPS-induced TNF-α increase at all tested concentrations.
Reduced IL-1β levels to 81.2 pg/mL (62.5 μM), 69.6 pg/mL (125 μM), 26.3 pg/mL (250 μM), and 13.2 pg/mL (500 μM) in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: murine macrophage RAW264.7 cells (with LPS stimulation)
Concentration: 62.5 μM, 125 μM, 250 μM, 500 μM
Incubation Time: 24 h
Result: Reduced iNOS protein levels to 28.2% of the LPS-alone group at 250 μM and 52.0% at 500 μM in a dose-dependent manner.
Reduced COX-2 protein levels to 35.4% of the LPS-alone group at 250 μM and 39.0% at 500 μM in a dose-dependent manner.\nReduced LPS-induced TLR4 protein levels in a dose-dependent manner.
Restored TLR4 levels to near basal levels at 500 μM.
In Vivo
Animal Model: BALB/c nu/nu (athymic nude, female, 4 weeks old)[2]
Dosage: 1 mg/kg; 5 mg/kg; 30 mg/kg
Administration: i.p.; three times per week; 30 days
Result: Significantly inhibited tumor growth compared to controls (p < 0.05).
Showed more profound inhibitory effects at 1 mg/kg and 5 mg/kg doses than at 30 mg/kg dose.
Reduced tumor weights in all treated groups relative to controls.
Significantly induced p53 protein and upregulated p27/Kip1 protein (3.51-fold relative to control), and downregulated cyclins D1 (0.21-fold relative to control), D3 (0.45-fold relative to control), and A (1.02-fold relative to control) in 1 mg/kg treated tumors.
Did not alter p53 protein, less strongly upregulated p27/Kip1 (1.74-fold relative to control), downregulated cyclins D1 (0.35-fold relative to control), D3 (0.88-fold relative to control), and A (0.63-fold relative to control), and slightly inhibited cyclin B protein levels in 30 mg/kg treated tumors.
Caused no gross toxicity (body weight changes, general appearance, organ effects) in any treated group.
Molecular Weight

196.20

Formula

C10H12O4
CAS No.
SMILES

O(C=1C=C(C(OC)=C2OCOC12)C)C
Structure Classification
Initial Source

Antrodia camphorata
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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4,7-Dimethoxy-5-methyl-1,3-benzodioxole Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4,7-Dimethoxy-5-methyl-1,3-benzodioxole165816-66-0Inhibitorinhibitorinhibit

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4,7-Dimethoxy-5-methyl-1,3-benzodioxole
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