4,7-Dimethoxy-5-methyl-1,3-benzodioxole
For research use only. We do not sell to patients.
- CAS No.: 165816-66-0
- Formula: C10H12O4
- Molecular Weight:196.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
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Help & FAQs
Biological Activity
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Neutrophil | IC50 |
26.09 μM
Compound: 5
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Inhibition of fMLP-induced superoxide production in human neutrophils
Inhibition of fMLP-induced superoxide production in human neutrophils
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[PMID: 17559265] |
In Vitro
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Cell Line:murine macrophage RAW264.7 cells (with LPS stimulation)
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Concentration:62.5 μM, 125 μM, 250 μM, 500 μM
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Incubation Time:24 h
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Result:Did not reduce cell viability compared to the untreated control group.
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Cell Line:murine macrophage RAW264.7 cells (with LPS stimulation)
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Concentration:62.5 μM, 125 μM, 250 μM, 500 μM
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Incubation Time:24 h
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Result:Slightly inhibited LPS-induced TNF-α increase at all tested concentrations.
Reduced IL-1β levels to 81.2 pg/mL (62.5 μM), 69.6 pg/mL (125 μM), 26.3 pg/mL (250 μM), and 13.2 pg/mL (500 μM) in a dose-dependent manner.
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Cell Line:murine macrophage RAW264.7 cells (with LPS stimulation)
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Concentration:62.5 μM, 125 μM, 250 μM, 500 μM
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Incubation Time:24 h
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Result:Reduced iNOS protein levels to 28.2% of the LPS-alone group at 250 μM and 52.0% at 500 μM in a dose-dependent manner.
Reduced COX-2 protein levels to 35.4% of the LPS-alone group at 250 μM and 39.0% at 500 μM in a dose-dependent manner.\nReduced LPS-induced TLR4 protein levels in a dose-dependent manner.
Restored TLR4 levels to near basal levels at 500 μM.
In Vivo
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Animal Model:BALB/c nu/nu (athymic nude, female, 4 weeks old)[2]
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Dosage:1 mg/kg; 5 mg/kg; 30 mg/kg
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Administration:i.p.; three times per week; 30 days
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Result:Significantly inhibited tumor growth compared to controls (p < 0.05).
Showed more profound inhibitory effects at 1 mg/kg and 5 mg/kg doses than at 30 mg/kg dose.
Reduced tumor weights in all treated groups relative to controls.
Significantly induced p53 protein and upregulated p27/Kip1 protein (3.51-fold relative to control), and downregulated cyclins D1 (0.21-fold relative to control), D3 (0.45-fold relative to control), and A (1.02-fold relative to control) in 1 mg/kg treated tumors.
Did not alter p53 protein, less strongly upregulated p27/Kip1 (1.74-fold relative to control), downregulated cyclins D1 (0.35-fold relative to control), D3 (0.88-fold relative to control), and A (0.63-fold relative to control), and slightly inhibited cyclin B protein levels in 30 mg/kg treated tumors.
Caused no gross toxicity (body weight changes, general appearance, organ effects) in any treated group.
Chemical Information
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CAS No. 165816-66-0
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Molecular Weight 196.20
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Formula C10H12O4
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SMILES
O(C=1C=C(C(OC)=C2OCOC12)C)C
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Structure Classification
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Initial Source
Antrodia camphorata
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4,7-Dimethoxy-5-methyl-1,3-benzodioxole Related Classifications
HY-N19139 Related Classifications
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