4-(Dimethylamino)phenacyl bromide-13C2,d6
Based on 1 Customer Validation
4-(Dimethylamino)phenacyl bromide-13C2,d6 (DmPABr-13C2,d6) is 13C-labeled 4-(Dimethylamino)phenacyl bromide (HY-W128417).
For research use only. We do not sell to patients.
- Purity: 98.14%
- Formula: C813C2H6D6BrNO
- Molecular Weight:250.13
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable or radioisotope-labeled compounds allow precise tracking and quantification of individual atoms in metabolic pathways. Stable isotopes generally do not change molecular properties but may slightly affect metabolic kinetics; radioactive isotopes may interfere with cells. Markers can distinguish endogenous and exogenous metabolites, reduce false positives, and are beneficial to quantification and reconstruction of metabolic pathways[2].
In cell culture or enzymatic reactions, the use of isotope markers can precisely control the concentration and exposure time, making it easy to study metabolic reactions and enzyme activities. Through stable isotope analytical metabolomics (SIRM), cellular metabolic networks can be studied, key metabolic nodes and regulatory mechanisms can be identified, and targets can be provided for compound development.
Isotope-labeled compounds can be used in competition binding experiments to evaluate the affinity and binding kinetics of compounds to receptors to help optimize design. Stable isotope labels are used as internal standards in mass spectrometry analysis to improve analysis accuracy and reproducibility and reduce matrix effect interference[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Isotope labeling can reveal specific steps in metabolic pathways. Using compounds with stable isotope labels at specific locations directly in humans or animal models can also help verify drug mechanisms and evaluate unexpected side effects, improving the accuracy and efficiency of clinical research[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 37904-72-6
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Appearance Solid
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Molecular Weight 250.13
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Formula C813C2H6D6BrNO
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Color Light yellow to yellow
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SMILES
BrCC(C1=CC=C(N([13C]([2H])([2H])[2H])[13C]([2H])([2H])[2H])C=C1)=O
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Synonyms
DmPABr-13C2,d6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (499.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Smith K A, et al. Soil and environmental analysis[M]. Marcel Dekker Incorporated, 2000.
[3]. Fan T W M, et al. Stable isotope-resolved metabolomics and applications for drug development[J]. Pharmacology & therapeutics, 2012, 133(3): 366-391. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9979 mL | 19.9896 mL | 39.9792 mL | 99.9480 mL |
| 5 mM | 0.7996 mL | 3.9979 mL | 7.9958 mL | 19.9896 mL | |
| 10 mM | 0.3998 mL | 1.9990 mL | 3.9979 mL | 9.9948 mL | |
| 15 mM | 0.2665 mL | 1.3326 mL | 2.6653 mL | 6.6632 mL | |
| 20 mM | 0.1999 mL | 0.9995 mL | 1.9990 mL | 4.9974 mL | |
| 25 mM | 0.1599 mL | 0.7996 mL | 1.5992 mL | 3.9979 mL | |
| 30 mM | 0.1333 mL | 0.6663 mL | 1.3326 mL | 3.3316 mL | |
| 40 mM | 0.0999 mL | 0.4997 mL | 0.9995 mL | 2.4987 mL | |
| 50 mM | 0.0800 mL | 0.3998 mL | 0.7996 mL | 1.9990 mL | |
| 60 mM | 0.0666 mL | 0.3332 mL | 0.6663 mL | 1.6658 mL | |
| 80 mM | 0.0500 mL | 0.2499 mL | 0.4997 mL | 1.2494 mL | |
| 100 mM | 0.0400 mL | 0.1999 mL | 0.3998 mL | 0.9995 mL |
4-(Dimethylamino)phenacyl bromide-13C2,d6 Related Classifications
HY-W128417S Related Classifications
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