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製品番号: HY-100153

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48740 RP

(別名: (Rac)-RP-55778)

48740 RP ((Rac)-RP-55778) is a platelet-activating factor (PAF) antagonist.

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CAS 番号: 93363-11-2
分子式: C₁₂H₁₁N₃OS
分子量:245.30

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

48740 RP 構造式

CAS 番号: 93363-11-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

48740 RP ((Rac)-RP-55778) is a platelet-activating factor (PAF) antagonist.

IC₅₀ & Target

PAF^[1]

体内実験

48740 RP ((Rac)-RP-55778) is a platelet-activating factor (PAF) antagonist. In animals treated with 48740 RP only, the number of platelets is increased at a time corresponding to 2 and 4 h after the exposure to lipopolysaccharide (LPS) and the number of eosinophils is also slightly increased. Treatment with 48740 RP in combination with the LPS exposure does not influence the increase in neutrophils seen 2 and 4 h after exposure. At 24 h the increase in the number of neutrophils is about half that in control animals. No effects are found on the LPS-induced increase in number of platelets. In animals pretreated with 48740 RP, there is a significant reduction in capillary permeability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 93363-11-2
分子量 245.30
分子式 C₁₂H₁₁N₃OS
SMILES

O=C(C(C=C1)=C2N1C(C3=CC=CN=C3)SC2)N
別名

(Rac)-RP-55778
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

Animal Administration^[1]

Guinea pigs of both sexes weighing 300 to 500 g are used for the determination of free lung cell responses and histopathologic examination. Male hamsters, weighing 100 g, are used for capillary permeability determinations. Guinea pigs are pretreated with an intraperitoneal injection of 48740 RP at 20 mg/kg in saline 1 h before exposure to lipopolysaccharide (LPS) and immediately thereafter. Groups of hamsters (n=6) are treated immediately before aerosol exposure, immediately after, and 3 h afterwards^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (276 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Rylander R, et al. Modulation of pulmonary inflammation after endotoxin inhalation with a platelet-activating factor antagonist (48740 RP). Int Arch Allergy Appl Immunol. 1988;86(3):303-7. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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