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48740 RP (Synonyms: RP-55778)

Cat. No.: HY-100153
Handling Instructions

48740 RP is a platelet-activating factor (PAF) antagonist.

For research use only. We do not sell to patients.

48740 RP Chemical Structure

48740 RP Chemical Structure

CAS No. : 93363-11-2

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48740 RP is a platelet-activating factor (PAF) antagonist.

IC50 & Target


In Vivo

48740 RP is a platelet-activating factor (PAF) antagonist. In animals treated with 48740 RP only, the number of platelets is increased at a time corresponding to 2 and 4 h after the exposure to lipopolysaccharide (LPS) and the number of eosinophils is also slightly increased. Treatment with 48740 RP in combination with the LPS exposure does not influence the increase in neutrophils seen 2 and 4 h after exposure. At 24 h the increase in the number of neutrophils is about half that in control animals. No effects are found on the LPS-induced increase in number of platelets. In animals pretreated with 48740 RP, there is a significant reduction in capillary permeability[1].


Please store the product under the recommended conditions in the Certificate of Analysis.

Animal Administration

Guinea pigs of both sexes weighing 300 to 500 g are used for the determination of free lung cell responses and histopathologic examination. Male hamsters, weighing 100 g, are used for capillary permeability determinations. Guinea pigs are pretreated with an intraperitoneal injection of 48740 RP at 20 mg/kg in saline 1 h before exposure to lipopolysaccharide (LPS) and immediately thereafter. Groups of hamsters (n=6) are treated immediately before aerosol exposure, immediately after, and 3 h afterwards[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight









Room temperature in continental US; may vary elsewhere

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Product Name:
48740 RP
Cat. No.:

48740 RP

Cat. No.: HY-100153