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Lipid peroxidation inhibitor 1 

Cat. No.: HY-U00319
Handling Instructions

Lipid peroxidation inhibitor 1 is a lipid peroxidation inhibitor with an IC50 of 0.07 μM.

For research use only. We do not sell to patients.

Lipid peroxidation inhibitor 1 Chemical Structure

Lipid peroxidation inhibitor 1 Chemical Structure

CAS No. : 142873-41-4

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Description

Lipid peroxidation inhibitor 1 is a lipid peroxidation inhibitor with an IC50 of 0.07 μM.

IC50 & Target

IC50: 0.07μM (lipid peroxidation)[1]

In Vitro

Among the compounds synthesized, Lipid peroxidation inhibitor 1 (26n) exhibits potent effects in the inhibition of lipid peroxidation, with an IC50 of 0.07 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Basic molecules 8a and 27 exhibit significant effects against (methamphetamine) MAP-induced hypermotility. Except in these compounds, a phenyl group adjacent to the methyl group in position 2 at a distance seems to be indispensable (compare compounds 26m, o, p with compounds Lipid peroxidation inhibitor 1 (26n), q, r). Among these compounds, Lipid peroxidation inhibitor 1 which has a phenylpiperidinyl group in position 2 is found to be most effective[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

364.52

Formula

C₂₄H₃₂N₂O

CAS No.

142873-41-4

SMILES

NC1=C(C)C(C)=C(OC(CN2CCC(C3=CC=CC=C3)CC2)(C)C4)C4=C1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[1]

To rat liver microsomes (S-9) (0.3 mg of protein/40 mM Tris-malate buffer (pH 7.4), 2.4 mL) (2.4 mL) is added a mixture (1:1; 0.1 mL) of aqueous FeCl2 solution (0.25 mM) and NADPH (3 mM). After incubation of the homogenate for 1 h at 37 °C, peroxide production is determined by the thiobarbituric acid method. The inhibitory activities on lipid peroxidation are expressed as IC50 values or percent inhibition as compare with the amount of production in the vehicle (DMSO) group[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

Five-week old male mice (25 to 35 g) are used. Following a 90 min acclimation period, the test compounds (including Lipid peroxidation inhibitor 1) suspended in 5% gum arabic are injected intraperitoneally in a volume of 20 mL/kg. Thirty minutes after treatment with test compounds, methamphetamine dissolved in saline is injected intraperitoneally at a dose of 1 mg/kg in a volume of 20 mL/kg. Immediately after methamphetamine injection, spontaneous motor activity is monitored for 90 min[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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