5-((S)-2,2-Dimethyltetrahydro-2H-pyran-4-yl)-1-((1S,2S)-2-methyl-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)cyclopropyl)-1H-indole-2-carboxylic acid

製品番号: HY-47663 純度: 99.96%: Data Sheet SDS COA 取扱説明書
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5-((S)-2,2-Dimethyltetrahydro-2H-pyran-4-yl)-1-((1S,2S)-2-methyl-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)cyclopropyl)-1H-indole-2-carboxylic acid (Compound 31k) is an intermediate of Orforglipron (HY-11218).

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5-((S)-2,2-Dimethyltetrahydro-2H-pyran-4-yl)-1-((1S,2S)-2-methyl-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)cyclopropyl)-1H-indole-2-carboxylic acid 構造式

CAS 番号 : 2212021-83-3

容量	価格（税別）	在庫状況	数量

>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 60	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 60	在庫あり	Estimated Time of Arrival: December 31
Solid
100 mg	$55	在庫あり	Estimated Time of Arrival: December 31
250 mg	$95	在庫あり	Estimated Time of Arrival: December 31
500 mg	$150	在庫あり	Estimated Time of Arrival: December 31
1 g	$226	在庫あり	Estimated Time of Arrival: December 31
5 g		お問い合わせ
10 g		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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製品説明

体外実験

Orforglipron (LY3502970) is an orally active agonist for Glucagon-like peptide-1 receptor (GLP-1R), which exhibits potency in ameliorates the type 2 diabete.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

411.46

分子式

C₂₂H₂₅N₃O₅

CAS 番号

2212021-83-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C(N1[C@]2(C(N3)=NOC3=O)[C@@H](C)C2)=CC4=C1C=CC([C@H]5CCOC(C)(C)C5)=C4

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Store at room temperature 3 years

*In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature 3 years)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (243.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4304 mL	12.1518 mL	24.3037 mL
5 mM	0.4861 mL	2.4304 mL	4.8607 mL
10 mM	0.2430 mL	1.2152 mL	2.4304 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.96%

Select Batch:

データシート (250 KB) SDS (394 KB)

COA (258 KB)

取扱説明書 (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4304 mL	12.1518 mL	24.3037 mL	60.7592 mL
	5 mM	0.4861 mL	2.4304 mL	4.8607 mL	12.1518 mL
	10 mM	0.2430 mL	1.2152 mL	2.4304 mL	6.0759 mL
	15 mM	0.1620 mL	0.8101 mL	1.6202 mL	4.0506 mL
	20 mM	0.1215 mL	0.6076 mL	1.2152 mL	3.0380 mL
	25 mM	0.0972 mL	0.4861 mL	0.9721 mL	2.4304 mL
	30 mM	0.0810 mL	0.4051 mL	0.8101 mL	2.0253 mL
	40 mM	0.0608 mL	0.3038 mL	0.6076 mL	1.5190 mL
	50 mM	0.0486 mL	0.2430 mL	0.4861 mL	1.2152 mL
	60 mM	0.0405 mL	0.2025 mL	0.4051 mL	1.0127 mL
	80 mM	0.0304 mL	0.1519 mL	0.3038 mL	0.7595 mL
	100 mM	0.0243 mL	0.1215 mL	0.2430 mL	0.6076 mL