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  4. 9-Amino-6-chloro-2-methoxyacridine

9-Amino-6-chloro-2-methoxyacridine  (Synonyms: ACMA)

Cat. No.: HY-118155 Purity: 99.88%
COA
SDS
Handling Instructions Technical Support

9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H+/solute antiport system.

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9-Amino-6-chloro-2-methoxyacridine

9-Amino-6-chloro-2-methoxyacridine 화학구조

CAS No. : 3548-09-2

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 2 publication(s) in Google Scholar

9-Amino-6-chloro-2-methoxyacridine Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE 9-Amino-6-chloro-2-methoxyacridine

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H+/solute antiport system[1].

Cellular Effect
Cell Line Type Value Description References
HT-22 EC50
7.41 3
Compound: 46
Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
[PMID: 24602904]
HT-22 EC50
7.41 3
Compound: 46
Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
[PMID: 24602904]
Panel NCI-60 cells GI50
1 3
Compound: 8
Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs
Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs
[PMID: 34731767]
Panel NCI-60 (60 carcinoma cell lines) GI50
1 3
Compound: 8
Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs
Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs
[PMID: 34731767]
HT-22 EC50
7.41 3
Compound: 46
Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
[PMID: 24602904]
Panel NCI-60 (60 carcinoma cell lines) GI50
1 3
Compound: 8
Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs
Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs
[PMID: 34731767]
ScN2a EC50
0.13 3
Compound: 19
Antiprion activity against scrapie prion protein RML infected mouse ScN2a cells assessed as reduction of scrapie prion protein accumulation by immunoblot analysis
Antiprion activity against scrapie prion protein RML infected mouse ScN2a cells assessed as reduction of scrapie prion protein accumulation by immunoblot analysis
[PMID: 18556207]
ScN2a EC50
0.13 3
Compound: 19
Antiprion activity against scrapie prion protein RML infected mouse ScN2a cells assessed as reduction of scrapie prion protein accumulation by immunoblot analysis
Antiprion activity against scrapie prion protein RML infected mouse ScN2a cells assessed as reduction of scrapie prion protein accumulation by immunoblot analysis
[PMID: 18556207]
T98G GI50
0.6 3
Compound: 8
Antiproliferative activity against human T98G cells assessed as cell growth inhibition incubated for 96 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human T98G cells assessed as cell growth inhibition incubated for 96 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 34731767]
T98G GI50
0.6 3
Compound: 8
Antiproliferative activity against human T98G cells assessed as cell growth inhibition incubated for 96 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human T98G cells assessed as cell growth inhibition incubated for 96 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 34731767]
ScN2a EC50
0.13 3
Compound: 19
Antiprion activity against scrapie prion protein RML infected mouse ScN2a cells assessed as reduction of scrapie prion protein accumulation by immunoblot analysis
Antiprion activity against scrapie prion protein RML infected mouse ScN2a cells assessed as reduction of scrapie prion protein accumulation by immunoblot analysis
[PMID: 18556207]
T98G GI50
0.6 3
Compound: 8
Antiproliferative activity against human T98G cells assessed as cell growth inhibition incubated for 96 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human T98G cells assessed as cell growth inhibition incubated for 96 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 34731767]
분자량

258.70

화학식

C14H11ClN2O
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

ClC1=CC=C2C(N=C3C=CC(OC)=CC3=C2N)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

용액&용해도
In Vitro: 

DMSO : 25 mg/mL (96.64 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8655 mL 19.3274 mL 38.6548 mL
5 mM 0.7731 mL 3.8655 mL 7.7310 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.88%

SDS (557 KB)

COA (247 KB) HNMR (250 KB) RP-HPLC (221 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8655 mL 19.3274 mL 38.6548 mL 96.6370 mL
5 mM 0.7731 mL 3.8655 mL 7.7310 mL 19.3274 mL
10 mM 0.3865 mL 1.9327 mL 3.8655 mL 9.6637 mL
15 mM 0.2577 mL 1.2885 mL 2.5770 mL 6.4425 mL
20 mM 0.1933 mL 0.9664 mL 1.9327 mL 4.8319 mL
25 mM 0.1546 mL 0.7731 mL 1.5462 mL 3.8655 mL
30 mM 0.1288 mL 0.6442 mL 1.2885 mL 3.2212 mL
40 mM 0.0966 mL 0.4832 mL 0.9664 mL 2.4159 mL
50 mM 0.0773 mL 0.3865 mL 0.7731 mL 1.9327 mL
60 mM 0.0644 mL 0.3221 mL 0.6442 mL 1.6106 mL
80 mM 0.0483 mL 0.2416 mL 0.4832 mL 1.2080 mL
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9-Amino-6-chloro-2-methoxyacridine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

9-Amino-6-chloro-2-methoxyacridine3548-09-2ACMAFluorescent DyepH sensitive fluorescent probesubstrateH+/solute antiport systemInhibitorinhibitorinhibit

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상품명:
9-Amino-6-chloro-2-methoxyacridine
Cat. No.:
HY-118155
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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