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Amcasertib  (Synonyms: BBI503)

製品番号: HY-17602 純度: 98.15%
COA 取扱説明書

Amcasertib (BBI503) is an orally active and small-molecule multi-kinase inhibitor. Amcasertib exhibits inhibitory activity against the NANOG and CD133 expression and cell viability in PC-9/GR cells. As an orally available cancer cell stemness kinase inhibitor with potential antineoplastic activity, it is currently being studied in phase I clinical trials in a number of cancers.

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Amcasertib 構造式

Amcasertib 構造式

CAS 番号 : 1129403-56-0

容量 価格(税別) 在庫状況 数量
Solution
10 mM * 1 mL in DMSO USD 222 在庫あり
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 222 在庫あり
Estimated Time of Arrival: December 31
Solid
1 mg USD 72 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 187 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 286 在庫あり
Estimated Time of Arrival: December 31
25 mg USD 583 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 946 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 1650 在庫あり
Estimated Time of Arrival: December 31
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

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製品説明

Amcasertib (BBI503) is an orally active and small-molecule multi-kinase inhibitor. Amcasertib exhibits inhibitory activity against the NANOG and CD133 expression and cell viability in PC-9/GR cells. As an orally available cancer cell stemness kinase inhibitor with potential antineoplastic activity, it is currently being studied in phase I clinical trials in a number of cancers.

体外実験

Amcasertib (0-1μM; 48h) inhibits the NANOG and CD133 expression in PC-9/GR cells. Amcasertib also significantly suppresses the growth of PC-9/GR cells in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: PC-9/GR cell
Concentration: 0, 0.3125, 0.625, 1.25, 2.5, 5 and 10μM
Incubation Time: 48 hours
Result: Suppressed the growth of PC-9/GR cells in a dose-dependent manner for 48 hours with a OD value decreased from over 1.5 to less than 0.2 (p< 0.0001).

Cell Viability Assay[1]

Cell Line: PC-9/GR cell
Concentration: 0, 0.3125, 0.625, 1.25, 2.5, 5 and 10μM
Incubation Time: 48 hours
Result: Suppressed the growth of PC-9/GR cells in a dose-dependent manner for 48 hours with a OD value decreased from over 1.5 to less than 0.2 (p< 0.0001).

Western Blot Analysis[1]

Cell Line: PC-9/GR cell
Concentration: 0, 0.1 and 1μM
Incubation Time: 48 hours
Result: Inhibited the NANOG and CD133 expression in PC-9/GR cells.

Western Blot Analysis[1]

Cell Line: PC-9/GR cell
Concentration: 0, 0.1 and 1μM
Incubation Time: 48 hours
Result: Inhibited the NANOG and CD133 expression in PC-9/GR cells.
臨床実験
分子量

539.69

分子式

C31H33N5O2S

CAS 番号
SMILES

O=C(C1=C(C)NC(/C=C2C(NC3=C/2C=C(C4=CSC(C5=CC=CC=C5)=N4)C=C3)=O)=C1C)NCCN(CC)CC

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 30 mg/mL (55.59 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8529 mL 9.2646 mL 18.5292 mL
5 mM 0.3706 mL 1.8529 mL 3.7058 mL
10 mM 0.1853 mL 0.9265 mL 1.8529 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (2.32 mM); Clear solution

*All of the co-solvents are available by MCE.
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参考文献
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製品名:
Amcasertib
製品番号:
HY-17602
数量:
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