1. GPCR/G Protein
  2. Endothelin Receptor

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate 

Cat. No.: HY-P1235A
Handling Instructions

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. ANP (1-28) inhibits endothelin-1 secretion in a dose-dependent way.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate Chemical Structure

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate Chemical Structure

CAS No. : 1366000-58-9

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500 μg USD 180 Get quote
1 mg USD 280 Get quote
5 mg USD 980 Get quote

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Other Forms of Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. ANP (1-28) inhibits endothelin-1 secretion in a dose-dependent way.

IC50 & Target

Endothelin-1[1]

In Vitro

Atrial natriuretic peptide (ANP) is a diuretic, natriuretic, and vasodilatory peptide hormone originally isolated from mammalian hearts. In cultured porcine endothelial cells the inhibition by porcine ANP (1-28) of immunoreactive endothelin-1 secretion after stimulation with Angiotensin II (Ang II) is paralleled by an increase in the cellular cGMP level. Porcine ANP (1-28) strongly inhibits immunoreactive endothelin-1 secretion in porcine aorta after stimulation with Ang II[1]. ANP is a cardiac hormone involved in electrolyte and fluid homeostasis. The inhibition by ANP of endothelin-1 secretion stimulated by angiotensin II (ANGII) and thrombin using cultured human umbilical-vein endothelial cells. Human ANP (1-28) inhibits immunoreactive (ir)-endothelin-1 secretion and increases cyclic GMP in the human umbilical-vein endothelial cells[2]. In glomeruli from normal rats, Human 125I-ANP (1-28) binds to a single population of high affinity receptors with a mean equilibrium dissociation constant of 0.46 nM. Human ANP (1-28) binds to the glomerular ANP receptor with high affinity stimulated cGMP accumulation. Human ANP (1-28) markedly stimulates cGMP generation, but not cAMP generation in normal rat glomeruli[3].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3184 mL 1.5921 mL 3.1842 mL
5 mM 0.0637 mL 0.3184 mL 0.6368 mL
10 mM 0.0318 mL 0.1592 mL 0.3184 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

3140.50

Formula

C₁₂₇H₂₀₃N₄₅O₃₉S₃.C₂H₄O₂

CAS No.

1366000-58-9

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate
Cat. No.:
HY-P1235A
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Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate

Cat. No.: HY-P1235A