1. Anti-infection
  2. Bacterial

BTZ043 

Cat. No.: HY-13579
Handling Instructions

BTZ043 is a inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), It can display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.[1]

For research use only. We do not sell to patients.
BTZ043 Chemical Structure

BTZ043 Chemical Structure

CAS No. : 1161233-85-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $99 In-stock
5 mg $90 In-stock
10 mg $160 In-stock
50 mg $580 In-stock
100 mg $880 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

BTZ043 is a inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), It can display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.[1] target: DprE1 IC50: <8 μM [2] in vitro: The inhibition of BTZ-resistant DprE1 followed the trend observed in the MIC measurements, with the C387G mutant being more resistant to inhibition by PyrBTZ01, PyrBTZ02, and BTZ043 (7- to 9-fold increases in IC50) than the C387S mutant (2.5- to 4-fold increases in IC50).[1] in vivo: BTZ-043 were administered at 100 mg/kg twice daily by gavage, and sulfamethoxazole/trimethoprim (SXT), at 100 mg/kg sulfamethoxazole, was used as a positive control.[2]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.3181 mL 11.5904 mL 23.1809 mL
5 mM 0.4636 mL 2.3181 mL 4.6362 mL
10 mM 0.2318 mL 1.1590 mL 2.3181 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

431.39

Formula

C₁₇H₁₆F₃N₃O₅S

CAS No.

1161233-85-7

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 13.3 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
BTZ043
Cat. No.:
HY-13579
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