Successful, we will reply to you quickly.

OK

Please select the quantity.

OK

Your message is being sent, please wait.

Close

test

Close

Send mail failed, please send again!

Close

Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

GSK2606414

HY-18072

(GSK 2606414; GSK-2606414)

GSK2606414

GSK2606414 Chemical Structure

GSK2606414 is an orally available, potent, and selective PERK inhibitor with an IC50 of 0.4 nM.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $109 In-stock
5 mg $99 In-stock
10 mg $130 In-stock
50 mg $350 In-stock
100 mg $540 In-stock
200 mg $900 In-stock
500 mg Get quote
1 g Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €107 In-stock
5 mg €97 In-stock
10 mg €127 In-stock
50 mg €343 In-stock
100 mg €529 In-stock
200 mg €882 In-stock
500 mg Get quote
1 g Get quote

* Please select Quantity before adding items.

Bulk Inquiry

Inquiry Information
Product name: GSK2606414
Cat. No.: HY-18072

GSK2606414 Data Sheet

  • View current batch:

    Purity: 99.72%

  • Network Version

    DataSheet

    Pdf Version Network Version

    MSDS

    Pdf Version

    COA

Related Compound Libraries

Biological Activity of GSK2606414

GSK2606414 is an orally available, potent, and selective PERK inhibitor with an IC50 of 0.4 nM.
IC50 Value: 0.4 nM [1]
Target:PERK
GSK2606414 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice. Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states [1]. It is implicated that PERK plays an important role in tumorigenesis and cancer cell survival.
 

Protocol (Extracted from published papers and Only for reference)

More

Chemical Information

M.Wt 451.44 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C24H20F3N5O
CAS No 1337531-36-8
Solvent & Solubility

DMSO: 200 mg/ml

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.2151 mL 11.0757 mL 22.1513 mL
5 mM 0.4430 mL 2.2151 mL 4.4303 mL
10 mM 0.2215 mL 1.1076 mL 2.2151 mL

References on GSK2606414

Inhibitor Kit

Related PERK Products

  • GSK2656157

    GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nM; is highly selective for PERK with IC50 values >100 nM against a panel of 300 kinases.

  • ISRIB trans-isomer

    ISRIB (trans-isomer) is a potent inhibitor of PERK signaling; inhibition of the ATF4 luciferase reporter in HEK293T cells with IC50 of 5 nM.