RGH-5526 (Synonyms: GYKI-11679)

Cat. No.: HY-100151: FAQs
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RGH-5526 (GYKI-11679) is a new antihypertensive agent.

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RGH-5526 Chemical Structure

CAS No. : 69579-13-1

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Description	RGH-5526 (GYKI-11679) is a new antihypertensive agent.
In Vivo	RGH-5526 (GYKI-11679) is a new antihypertensive agent. Results show a sharp (61%) reduction in the hypothalamic Noradrenaline (NA) level 2 h after the administration of 10 mg/kg of RGH-5526, and this effect lasts for 4 to 6 h. It is demonstrated that RGH-5526 exerts a greater NA lowering effect in the hypothalamus than in the periphery. RGH-5526 does not influence the hypothalamic monoamine oxidase (MAO)-activity following prolonged treatment^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	335.40
Formula	C₁₆H₂₅N₅O₃
CAS No.	69579-13-1
SMILES	C/C(CC(OC(C)(C)C)=O)=N\NC1=NN=C(N2CCOCC2)C=C1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (266 KB) Handling Instructions (2659 KB)
References	[1]. Huszti Z, et al. Influence on turnover and level of hypothalamic noradrenaline by a new antihypertensive agent (GYKI 11679). J Neurochem. 1981 Nov;37(5):1272-81. [Content Brief]

Animal Administration
^[1]

Rats are used and treated with GYKI-11679 (0.5 mL of 1% Tween 80 suspension) at various dosages. They are killed at the specified times by decapitation; the heart is immediately removed, cut open, and rinsed in an isotonic saline solution. The brain is placed on ice and the hypothalamus is dissected. The tissues are weighed, homogenized in 5% trichloroacetic acid (TCA) containing 0.2% EDTA and ascorbic acid, and centrifuged for 1 h at 5000×g. The supernatant is processed on alumina and noradrenaline in the eluate is determined spectrofluorimetrically^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Huszti Z, et al. Influence on turnover and level of hypothalamic noradrenaline by a new antihypertensive agent (GYKI 11679). J Neurochem. 1981 Nov;37(5):1272-81. [Content Brief]

RGH-5526 Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RGH-552669579-13-1GYKI-11679RGH5526RGH 5526GYKI11679GYKI 11679OthersInhibitorinhibitorinhibit

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RGH-5526 (Synonyms: GYKI-11679)

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