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RGH-5526 (Synonyms: GYKI-11679)

Cat. No.: HY-100151
Handling Instructions

GYKI-11679 is a new antihypertensive agent.

For research use only. We do not sell to patients.

RGH-5526 Chemical Structure

RGH-5526 Chemical Structure

CAS No. : 69579-13-1

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Description

GYKI-11679 is a new antihypertensive agent.

In Vivo

GYKI-11679 is a new antihypertensive agent. Results show a sharp (61%) reduction in the hypothalamic Noradrenaline (NA) level 2 h after the administration of 10 mg/kg of GYKI-11679, and this effect lasts for 4 to 6 h. It is demonstrated that GYKI-11679 exerts a greater NA lowering effect in the hypothalamus than in the periphery. GYKI-11679 does not influence the hypothalamic monoamine oxidase (MAO)-activity following prolonged treatment[1].

References
Animal Administration
[1]

Rats are used and treated with GYKI-11679 (0.5 mL of 1% Tween 80 suspension) at various dosages. They are killed at the specified times by decapitation; the heart is immediately removed, cut open, and rinsed in an isotonic saline solution. The brain is placed on ice and the hypothalamus is dissected. The tissues are weighed, homogenized in 5% trichloroacetic acid (TCA) containing 0.2% EDTA and ascorbic acid, and centrifuged for 1 h at 5000×g. The supernatant is processed on alumina and noradrenaline in the eluate is determined spectrofluorimetrically[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

335.40

Formula

C₁₆H₂₅N₅O₃

CAS No.

69579-13-1

SMILES

C/C(CC(OC(C)(C)C)=O)=N\NC1=NN=C(N2CCOCC2)C=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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RGH-5526
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Cat. No.: HY-100151