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  4. Gelucire 44/14

Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable agents including insulin and calcitonin by pulmonary delivery.

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Gelucire 44/14

Gelucire 44/14 構造式

CAS 番号 : 121548-04-7

容量 価格（税別） 在庫状況 数量
25 g $50 在庫あり
50 g $80 在庫あり
100 g $130 在庫あり
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Gelucire 44/14 関連抗体

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製品説明

Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable agents including insulin and calcitonin by pulmonary delivery.

体内実験

Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable drugs including insulin and calcitonin by pulmonary delivery. It is found that pulmonary absorptions of FD4, FD10 and FD70 are enhanced in different degree by Gelucire 44/14 in a concentration-dependent manner, and the maximal absorption-enhancing effect is obtained when the concentration of Gelucire 44/14 reaches to 2.0% (w/v). It is also found that the absorption enhancing ability of Gelucire Gelucire 44/14 is correlated with the molecular weight of model drugs, and the highest absorption enhancement ratio of Gelucire Gelucire 14/44 is observed when the molecular weight of model drugs reaches to nearly 10000 Da[1].

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CAS 番号
Appearance

Oil

Color

Off-white to light yellow

SMILES

[Gelucire 44/14]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Pure form -20°C 3 years
  4°C 2 years
溶剤 & 溶解度
体外: 

Ethanol : 100 mg/mL (Need ultrasonic)

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純度とドキュメンテーション

純度: 96.3%

COA (245 KB)

取扱説明書 (2659 KB)
参考文献
動物実験
[1]

Male Sprague Dawley rats are used to evaluate the pulmonary membrane toxicity of Gelucire 44/14. PBS (pH 7.4) with or without Gelucire 44/14 are directly administered to the tracheae of the rats according to the in-situ pulmonary absorption experiments. Four hours later, the rats are bled from the abdominal aorta, and then PBS (pH7.4) is perfused into the rat lung along the trachea. Afterwards, bronchoalveolar lavage fluid (BALF) of rat in each group is collected and kept in ice immediately until determination[1].

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参考文献
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Gelucire 44/14 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Keywords:

Gelucire 44/14121548-04-7Biochemical Assay ReagentsInhibitorinhibitorinhibit

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Gelucire 44/14
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HY-Y1892
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