1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. HA130

HA130 

Cat. No.: HY-19329 Purity: 98.90%
Handling Instructions

HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM.

For research use only. We do not sell to patients.

HA130 Chemical Structure

HA130 Chemical Structure

CAS No. : 1229652-21-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 168 In-stock
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
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100 mg USD 900 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM.

IC50 & Target[1]

Autotaxin

28 nM (IC50)

In Vitro

HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation[1].

In Vivo

HA130 slows T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle[1].
The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs)[2].

Molecular Weight

463.29

Formula

C₂₄H₁₉BFNO₅S

CAS No.

1229652-21-4

SMILES

O=C1N(CC2=CC=C(F)C=C2)C(S/C1=C\C3=CC=C(OCC4=CC(B(O)O)=CC=C4)C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 39 mg/mL (84.18 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1585 mL 10.7924 mL 21.5848 mL
5 mM 0.4317 mL 2.1585 mL 4.3170 mL
10 mM 0.2158 mL 1.0792 mL 2.1585 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.90%

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HA130
Cat. No.:
HY-19329
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