1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. HA130


Cat. No.: HY-19329 Purity: 99.46%
COA Handling Instructions

HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM.

For research use only. We do not sell to patients.

HA130 Chemical Structure

HA130 Chemical Structure

CAS No. : 1229652-21-4

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO USD 67 In-stock
5 mg USD 66 In-stock
10 mg USD 110 In-stock
50 mg USD 330 In-stock
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Customer Review

Based on 5 publication(s) in Google Scholar

Top Publications Citing Use of Products

    HA130 purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2020 Jul 30.  [Abstract]

    Supernatant (sup) from HUVECs stimulated with or without Hcy (100 μM) for 24 h are transferred to T cell and cultured with or without HA130 (1 μM) for 24 h. HA130 suppresses the activation of FAK and Src in T cells caused by Hcy-stimulated HUVEC supernatant.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review


    HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM.

    IC50 & Target[1]


    28 nM (IC50)

    In Vitro

    HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    HA130 slows T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle[1].
    The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs)[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight




    CAS No.



    Light yellow to yellow




    Room temperature in continental US; may vary elsewhere.

    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 39 mg/mL (84.18 mM)

    *"≥" means soluble, but saturation unknown.

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1585 mL 10.7924 mL 21.5848 mL
    5 mM 0.4317 mL 2.1585 mL 4.3170 mL
    10 mM 0.2158 mL 1.0792 mL 2.1585 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (5.40 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (5.40 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.46%

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    HA130 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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