1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. HA130

HA130 

Cat. No.: HY-19329 Purity: 99.43%
Handling Instructions

HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM.

For research use only. We do not sell to patients.

HA130 Chemical Structure

HA130 Chemical Structure

CAS No. : 1229652-21-4

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 168 In-stock
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
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100 mg USD 900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    HA130 purchased from MCE. Usage Cited in: Cell Mol Life Sci. 2020 Jul 30.

    Supernatant (sup) from HUVECs stimulated with or without Hcy (100 μM) for 24 h are transferred to T cell and cultured with or without HA130 (1 μM) for 24 h. HA130 suppresses the activation of FAK and Src in T cells caused by Hcy-stimulated HUVEC supernatant.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM.

    IC50 & Target[1]

    Autotaxin

    28 nM (IC50)

    In Vitro

    HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation[1].

    In Vivo

    HA130 slows T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle[1].
    The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs)[2].

    Molecular Weight

    463.29

    Formula

    C₂₄H₁₉BFNO₅S

    CAS No.

    1229652-21-4

    SMILES

    O=C1N(CC2=CC=C(F)C=C2)C(S/C1=C\C3=CC=C(OCC4=CC(B(O)O)=CC=C4)C=C3)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 39 mg/mL (84.18 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1585 mL 10.7924 mL 21.5848 mL
    5 mM 0.4317 mL 2.1585 mL 4.3170 mL
    10 mM 0.2158 mL 1.0792 mL 2.1585 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.40 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.40 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.43%

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    Keywords:

    HA130HA 130HA-130Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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    Product Name:
    HA130
    Cat. No.:
    HY-19329
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