Rubia cordifolia L.

Purpurin is a natural anthraquinone compound from Rubia cordifolia L.. Purpurin has antidepressant-like effects.

Alizarin is a natural dye. Alizarin can be extracted from the roots of madder plant. Alizarin activates AMPK and VEGFR2/eNOS pathway. Alizarin regulates PI3K/Akt and inhibits NF-κB pathway. Alizarin enhances CYP1A1 enzyme activity. Alizarin has protective effects on hypertension and vascular endothelial dysfunction. Alizarin has anti-tumor activity against multiple cancers including pancreatic cancer, breast cancer, osteosarcoma and liver cancer. Alizarin has been widely used as a pigment in textile fabrics and paintings.

Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway.

Rubiadin-1-methyl ether is an orally potent NF-κB p65 inhibitor and autophagy inhibitor. Rubiadin-1-methyl ether inhibits RANKL-induced phosphorylation and nuclear translocation of p65, suppresses BECN1 transcription, blocks LC3 conversion and autophagosome formation, thereby reducing the levels of BECN1 mRNA and Beclin1 protein. Rubiadin-1-methyl ether inhibits osteoclastogenesis, cell proliferation, macrophage M2 polarization and the TGF-β1 signaling pathway, and effectively alleviates pulmonary inflammation. Rubiadin-1-methyl ether is widely used in research on osteoporosis, pulmonary fibrosis, idiopathic pulmonary fibrosis, acute lung injury and other related diseases.

2-Amino-3-carboxy-1,4-naphthoquinone is the electron transfer mediator. 2-Amino-3-carboxy-1,4-naphthoquinone changes glucose metabolism of the homofermentative lactic acid bacteria.

Purpurin (Standard) is the analytical standard of Purpurin. This product is intended for research and analytical applications. Purpurin is a natural anthraquinone compound from Rubia cordifolia L.. Purpurin has antidepressant-like effects.

Mollugin (Standard) is the analytical standard of Mollugin. This product is intended for research and analytical applications. Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway.

Rubia cordifolia polysaccharide is a polysaccharide derived from Rubia cordifolia.

Lucidin (NSC 30546) is a natural component of madder and can induce mutations in bacterial and mammalian cells.

Anthragallol can insert base pairs of DNA. Anthragallol exhibits cytotoxicity by binding to DNA.

RA-XI is a bicyclic hexapeptide isolated from Rubia cordifolia with antitumour activity.

Lucidin primeveroside (Lucidin 3-O-β-primeveroside) is an anthraquinone derivative present in madder root, which has been used as a coloring agent and food additive. Lucidin primeveroside can be metabolically converted to genotoxic compound Lucidin, which subsequently forms lucidin-specific DNA adducts.

6-Hydroxyrubiadin, a natural anthraquinone, may be a potential therapeutic candidate for the treatment of inflammation and inflammatory diseases.

Alizarin (Standard) is the analytical standard of Alizarin. This product is intended for research and analytical applications. Alizarin is a natural dye extracted from the roots of madder plant and has been widely used as a pigment in textile fabrics and paintings.

Rubiasin A is an anthracene derivative found in the combined roots and stems of Rubia cordifolia. Rubiasin A shows no antiproliferative activity in testing involving colon cancer cells.

Tridecan-4-ol is an alcohol compound that can be extracted from Rubia cordifolia L.

Lucidin (Standard) is the analytical standard of Lucidin. This product is intended for research and analytical applications. Lucidin (NSC 30546) is a natural component of madder and can induce mutations in bacterial and mammalian cells.

Rubilactone is an active product that can be derived from (Rubia cordifolia). Rubilactone has antitumor, viral inhibition activities.

Rubicordifolin is a natural product that can be isolated from Rubia cordifolia. Rubicordifolin inhibits the growth of sarcoma ascites in mice. Rubicordifolin has significant cytotoxic activity both in vitro and in vivo.

3-methoxymollugin is a compound that can be isolated from Rubia cordifolia and is cytotoxic..