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  2. Parasite
  3. PPA-904

PPA-904 

Cat. No.: HY-U00128 Purity: 97.97%
Handling Instructions

PPA-904 is a specific phenothiazine photosensitizer used in photodynamic therapy.

For research use only. We do not sell to patients.

PPA-904 Chemical Structure

PPA-904 Chemical Structure

CAS No. : 30189-85-6

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Estimated Time of Arrival: December 31
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Description

PPA-904 is a specific phenothiazine photosensitizer used in photodynamic therapy.

IC50 & Target

Parasite[1]

In Vivo

Topical PPA904 photodynamic therapy is a promising treatment for cutaneous leishmaniasis. The best curative PPA904-photodynamic therapy regimen is achieved under the conditions of a longer duration of topical application time (90 minutes) and several (three) consecutive treatments with 4-day intervals between treatments[1]. PPA904-PDT can provide an immunomodulating, dose-dependent efflux on IL-12p70 production. This mechanism could be responsible for promoting a more rapid healing in PPA904-PDT treated mice[2]. Treatment of PPA904 is well tolerated with no reports of pain or other safety issues. PPA904 treated subjects show a reduction in bacterial load immediately post-treatment. After 3 months, 50% (four of eight) of subjects with actively treated chronic leg ulcer show complete healing, compared with 12% (one of eight) of subjects on placebo[3].

Clinical Trial
Molecular Weight

532.62

Formula

C₂₈H₄₂BrN₃S

CAS No.

30189-85-6

SMILES

CCCCN(C1=CC2=[S+]C3=C(C=CC(N(CCCC)CCCC)=C3)N=C2C=C1)CCCC.[Br-]

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References
Animal Administration
[1]

Mice: 106 metacyclic parasites in 20 mL of PBS are inoculated intradermally into the ears of 6- to 8-week-old BALB/c female mice. A PPA904 cream is applied topically onto the lesion under dark conditions. The areas in the right ear are then irradiated with LC-122A, non-coherent light source equipped with a broadband optical filter, which is inserted into the light delivery system. The filter peaks at 665 nm and has a half-band width of 30 nm. A fluence of 50 J/cm2 (50 mW/cm2) is delivered to the lesion on the right ear, while the left ear (and left ears of the other mice in this group) serves as the drug only group. The ears from mice with no procedure serve as the infected nontreated group. Mice are sacrificed 5 days after photodynamic therapy. Parasite loads in the ears are determined[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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PPA-904
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