1. Membrane Transporter/Ion Channel
  2. Proton Pump
  3. Picoprazole

Picoprazole 

Cat. No.: HY-15384
Handling Instructions

Picoprazole is a specific inhibitor of H+/K+-ATPase with IC50 of 3.1±0.4 μM.

For research use only. We do not sell to patients.

Picoprazole Chemical Structure

Picoprazole Chemical Structure

CAS No. : 78090-11-6

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Description

Picoprazole is a specific inhibitor of H+/K+-ATPase with IC50 of 3.1±0.4 μM.

IC50 & Target

IC50: 3.1±0.4 μM (H+/K+-ATPase)[1]

In Vitro

Picoprazole inhibits the H+/K+-ATPase activity in a concentration-dependent manner. The IC50 value is 3.1±0.4 μM[1]. Picoprazole is a specific inhibitor of H+/K+-ATPase and binds to 100-kDa polypeptides of the enzyme, dose dependently inhibited opening of the Cl- conductance by Cu2+-o-phenanthroline, indicating that the Cl- conductance is part of the function of the H+/K+-ATPase[2]. The inhibitory effect of the three benzimidazole derivatives Timoprazole, Picoprazole, and Omeprazole on histamine and dbcAMP stimulated 14C-aminopyrine accumulation (H+ secretion) has been studied in isolated and enriched guinea-pig parietal cells. All compounds tested inhibit H+ secretion in a concentration dependent manner with IC50 values of 8.5±1.9 μM for Timoprazole, 3.9±0.7 μM for Picoprazole, and 0.13±0.03 μM for Omeprazole[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

343.40

Formula

C₁₇H₁₇N₃O₃S

CAS No.
SMILES

O=C(C1=C(C)C=C2N=C(S(CC3=NC=CC=C3C)=O)NC2=C1)OC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PicoprazoleProton PumpInhibitorinhibitorinhibit

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Picoprazole
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