Solutol HS-15
Based on 29 publication(s) in Google Scholar
Solutol HS-15, a Macrogol 15 hydroxy stearate, is a permeability enhancer.
For research use only. We do not sell to patients.
- CAS No.: 61909-81-7
- Formula: (C2H4O)nC18H36O3
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-Y0873A
PEG400 -
HY-Y0873
PEG300Neutral Polymer -
HY-101103
HP-β-CDCo-solvent -
HY-Y1890
Cremophor EL-40Surfactant -
HY-17031
SBE-β-CDExcipient -
HY-148439
DaraxonrasibRAS(ON) Inhibitor -
HY-Y1891
Tween 80 -
HY-Y0320
Dimethyl sulfoxide, meets analytical specification of Ch.P.Aprotic Solvent -
HY-W042416
N,N-DimethylacetamideAnti-inflammatory agent -
HY-Y1275
N-MethylpyrrolidoneFive-membered Cyclic Amide -
HY-Y1888
Corn oil -
HY-10219
RapamycinmTOR Inhibitor
Publications Citing Use of MedChemExpress (MCE) Solutol HS-15
More- Nature. 2026 Sep 23.
- Nature. 2024 Apr;628(8009):835-843. [Abstract]
- Cancer Cell. 2022 Dec 12;40(12):1566-1582.e10. [Abstract]
- Cancer Cell. 2020 Dec 14;38(6):844-856.e7. [Abstract]
- Nat Immunol. 2025 Apr 11. [Abstract]
- Nat Commun. 2023 Sep 18;14(1):5666. [Abstract]
- Nat Chem Biol. 2025 May 26. [Abstract]
- Cell Rep Med. 2024 Dec 17;5(12):101837. [Abstract]
- Cell Rep Med. 2023 Apr 18;4(4):101015. [Abstract]
- Carbohydr Polym. 2025 Sep 1:363:123707. [Abstract]
- Adv Healthc Mater. 2026 Aug;15(30):e71409.
- Mol Ther Oncol. 2026 Aug 1;34(3):201315.
- ACS Appl Mater Interfaces. 2025 Dec 31. [Abstract]
- Pharmaceutics. 2025 Dec 11;17(12):1599. [Abstract]
- Eur J Med Chem. 2022 Mar 15:232:114166. [Abstract]
- Front Pharmacol. 2021 Nov 11;12:773126. [Abstract]
- Molecules. 2022 Aug 25;27(17):5448. [Abstract]
- Eur J Pharm Biopharm. 2024 Feb:195:114179. [Abstract]
- ACS Infect Dis. 2025 Jan 10;11(1):181-196. [Abstract]
- Cancer Med. 2025 Nov;14(22):e71399. [Abstract]
- Invest New Drugs. 2022 Oct;40(5):922-933. [Abstract]
- Biomed Chromatogr. 2026 Jun;40(6):e70467. [Abstract]
- SSRN. 2026 Sep 30.
- The University of Tennessee Health Science Center. 2026.
- Georgetown University. 2026.
- University of Toronto. 2026.
- McGill University. 2025.
- Res Sq. 2025 Feb 11:rs.3.rs-4138879. [Abstract]
- Res Sq. 2023 Apr 26:rs.3.rs-2861359. [Abstract]
Biological Activity
Description
In Vitro
Solutol HS-15 is used to increase the aqueous solubility of Biopharmaceutical Classification System (BCS) Class 2 and 4 lipophilic molecules. Solutol HS-15 has shown an enhancement in permeability of medium sized biological drugs across epithelia[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 61909-81-7
-
Appearance Oil
-
Formula (C2H4O)nC18H36O3
-
Color Colorless to off-white
-
SMILES
OCCOC(CCCCCCCCCCC(O)CCCCCC)=O.[n]
-
Synonyms
Polyethylene glycol 12-hydroxystearate
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (29)
-
Journal Impact Factor
-
Most Recent
-
-
Nature
2024 Apr;628(8009):835-843. PMID: 38600381 -
Cancer Cell
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. [Abstract]2022 Dec 12;40(12):1566-1582.e10. PMID: 36306790 -
Cancer Cell
Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors. [Abstract]2020 Dec 14;38(6):844-856.e7. PMID: 33186520 -
Nat Immunol
2025 Apr 11. PMID: 40217111 -
Nat Commun
Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection. [Abstract]2023 Sep 18;14(1):5666. PMID: 37723181 -
Nat Chem Biol
2025 May 26. PMID: 40419770 -
Cell Rep Med
Structure-guided development of selective caseinolytic protease P agonists as antistaphylococcal agents. [Abstract]2024 Dec 17;5(12):101837. PMID: 39615486 -
Cell Rep Med
A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer. [Abstract]2023 Apr 18;4(4):101015. PMID: 37075701 -
Carbohydr Polym
A rapid and efficient microenvironment improving hyaluronic acid microneedle dressing for burn wound synergistic treatment. [Abstract]2025 Sep 1:363:123707. PMID: 40441824 -
-
-
ACS Appl Mater Interfaces
Mitochondrial Rapid Accumulation and Self-Enhanced Penetrating Nanomedicine for Tumor Multi-role Treatment. [Abstract]2025 Dec 31. PMID: 41476371 -
Pharmaceutics
Therapeutic Delivery of Phloretin by Mixed Emulsifier-Stabilized Nanoemulsion Alleviated Cerebral Ischemia/Reperfusion Injury. [Abstract]2025 Dec 11;17(12):1599. PMID: 41471114 -
Eur J Med Chem
Semisynthesis and biological evaluation of (+)-sclerotiorin derivatives as antitumor agents for the treatment of hepatocellular carcinoma. [Abstract]2022 Mar 15:232:114166. PMID: 35152092 -
Front Pharmacol
Herb-Drug Interaction Between Xiyanping Injection and Lopinavir/Ritonavir, Two Agents Used in COVID-19 Pharmacotherapy. [Abstract]2021 Nov 11;12:773126. PMID: 34899329 -
Molecules
Development and Validation of a Sensitive and Specific LC-MS/MS Method for IWR-1-Endo, a Wnt Signaling Inhibitor: Application to a Cerebral Microdialysis Study. [Abstract]2022 Aug 25;27(17):5448. PMID: 36080214 -
Eur J Pharm Biopharm
Cysteine-modified PEGylated nanoparticles for targeted delivery of methylprednisolone to pancreatitis. [Abstract]2024 Feb:195:114179. PMID: 38199584 -
ACS Infect Dis
nsP2 Protease Inhibitor Blocks the Replication of New World Alphaviruses and Offer Protection in Mice. [Abstract]2025 Jan 10;11(1):181-196. PMID: 39737550 -
Cancer Med
CDH11 Contributes to Bladder Cancer Progression via Regulation of Mitochondrial Energy Metabolism. [Abstract]2025 Nov;14(22):e71399. PMID: 41263259 -
Invest New Drugs
MY11 exerts antitumor effects through activation of the NF-κB/PUMA signaling pathway in breast cancer. [Abstract]2022 Oct;40(5):922-933. PMID: 35759135 -
Biomed Chromatogr
LC-MS/MS Determination of the Absorption and Distribution Dynamics of the Bioactive Alkaloid Dendrobine Derived From Chinese Dendrobium nobile. [Abstract]2026 Jun;40(6):e70467. PMID: 42044949 -
-
-
-
-
-
Res Sq
2025 Feb 11:rs.3.rs-4138879. PMID: 39989975 -
Res Sq
2023 Apr 26:rs.3.rs-2861359. PMID: 37162820
Solvent & Solubility
In Vitro:
Ethanol : 100 mg/mL (Need ultrasonic)
H2O : 100 mg/mL (Need ultrasonic)
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Solutol HS-15 Related Classifications
HY-Y1893 Related Classifications
Powered by Bioz