2. Signalwege
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

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Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Art. -Nr. Produktname Wirkung Reinheit Chemical Structure
  • HY-125774
    Bimatoprost acid
    		Agonist 99.96%
    Bimatoprost acid (17-Phenyl trinor PGF2α), the acid hydrolysis product of Bimatoprost (HY-B0191), is a potent agonist of prostaglandin FP receptor.
    Bimatoprost acid
  • HY-B0195A
    Tranilast sodium
    		Inhibitor
    Tranilast sodium (MK-341 sodium) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells.
    Tranilast sodium
  • HY-A0096S
    Iloprost-d4
    		Agonist
    Iloprost-d4 (Ciloprost-d4) is the deuterium labeled Iloprost. Iloprost (ZK 36374) is a synthetic analogue of prostacyclin PGI2.
    Iloprost-d<sub>4</sub>
  • HY-137308
    15(R)-Prostaglandin D2
    		99.9%
    15(R)-Prostaglandin D2 is a potential prostatic hormone DP(2) receptor (Prostaglandin Receptor) agonist with anti-inflammatory activity. 15(R)-Prostaglandin D2 increases actin polymerization in human eosinophils and increases cAMP levels in platelets.
    15(R)-Prostaglandin D2
  • HY-B0774R
    Seratrodast (Standard)
    		Antagonist
    Seratrodast (Standard) is the analytical standard of Seratrodast. This product is intended for research and analytical applications. Seratrodast (AA 2414), an orally active antiasthmatic agent, is a thromboxane A2 receptor (TP) antagonist and ferroptosis inhibitor. Seratrodast reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression. Seratrodast exhibits anti-asthmatic and anti-epileptic activity.
    Seratrodast (Standard)
  • HY-N0499R
    Cyanidin Chloride (Standard)
    		Inhibitor
    Cyanidin Chloride (IdB 1027) (Standard) is the analytical standard of Cyanidin Chloride (IdB 1027). This product is intended for research and analytical applications. Cyanidin Chloride (IdB 1027) is an orally active antioxidant and enzyme inhibitor. Cyanidin Chloride has IC50 values of 90 μM and 60 μM against PGHS-1 and PGHS-2, respectively. Cyanidin Chloride exhibits excellent antioxidant and anti-inflammatory activities, scavenges free radicals, inhibits lipid peroxidation, and protects DNA from cleavage. Cyanidin Chloride can be used in the research of inflammatory diseases.
    Cyanidin Chloride (Standard)
  • HY-158332
    Sulotroban
    		Antagonist 99.29%
    Sulotroban (SKF-95587; BM-13177) is a selective antagonist for thromboxane A2 receptor (TXA2 Receptor). Sulotroban exhibits inhibitory activity against carbocyclic thromboxane A2- and endoperoxide-induced vasoconstrictor. Sulotroban inhibits platelets aggregation.
    Sulotroban
  • HY-130304
    8-Isoprostaglandin E2
    		Activator 98.31%
    8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A2 (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway.
    8-Isoprostaglandin E2
  • HY-B0813R
    Treprostinil diethanolamine (Standard)
    		Agonist
    Geniposide (Standard) is the analytical standard of Geniposide. This product is intended for research and analytical applications. Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.
    Treprostinil diethanolamine (Standard)
  • HY-128538
    Sepetaprost
    		Agonist
    Sepetaprost (ONO-9054) is a dual agonist of the prostaglandin E3 receptor and prostaglandin F receptor. Sepetaprost reduces intraocular pressure in animal models. Sepetaprost is applicable for research on ocular hypertension and open-angle glaucoma.
    Sepetaprost
  • HY-142658
    BAY-6672
    		Antagonist
    BAY-6672, a chemical probe, is a potent and selective human Prostaglandin F (FP) receptor antagonist with an IC50 value of 11 nM.
    BAY-6672
  • HY-50175A
    Laropiprant sodium
    		Antagonist
    Laropiprant sodium is a potent and selective DP receptor antagonist with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively.
    Laropiprant sodium
  • HY-112604
    MK-8318
    		Antagonist
    MK-8318 is a potent and selective CRTh2 receptor antagonist with a Ki of 5.0 nM.
    MK-8318
  • HY-163376
    17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide
    17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide (compound 17-CF3PTPG2α EA) is a lipophilic analog of 17-trifluoromethylphenyl trinor PGF2α.
    17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide
  • HY-403733B
    (+)-JJ-450
    		Inhibitor
    (+)-JJ-450 is a non-competitive antagonist targeting the androgen receptor (AR) that inhibits AR nuclear localization and transcriptional activity in the absence of androgen. (+)-JJ-450 is less active than (-)-JJ-450 (HY-403733A) in inhibiting prostate-specific antigen (PSA) expression in LN95 cells, possibly because (+)-JJ-450 targets the ligand binding domain (LBD) of AR. (+)-JJ-450 inhibits the transcriptional activity of AR and its splice variants (e.g., ARv7) by promoting the degradation of unliganded AR in the nucleus and reducing the binding of AR to androgen response elements (AREs). (+)-JJ-450 can be used in castration-resistant prostate cancer (CRPC) studies that are resistant to enzalutamide (MDV3100) (HY-70003).
    (+)-JJ-450
  • HY-105052
    SC 34301
    SC 34301 (Enisoprost) is a potent and orally active PGE1 analog. SC 34301 significantly reduces bacterial translocation and improves survival for burned mice.
    SC 34301
  • HY-159704
    9-Keto-latanoprost
    		Control
    9-keto latanoprost is a derivative of the F-prostaglandin (FP) receptor agonist Latanoprost (HY-B0577).
    9-Keto-latanoprost
  • HY-106195
    L 377202
    		Ligand
    L 377202 is a peptide-drug conjugate (PDC). L 377202 consists of Doxorubicin (HY-15142A) and a prostate-specific antigen (PSA)-hydrolyzable peptide. L 377202 demonstrates strong inhibitory effects on PSA-secreting prostate cancer cells. L 377202 is promising for research of prostate cancer.
    L 377202
  • HY-124192
    Amogastrin
    		Inhibitor
    Amogastrin is a tetrapeptide that stimulates gastric extraction of 99mTc pertechnetate. Amogastrin can be used for the research of gastric mucosal disease imaging. Amogastrin stimulates the production of prostate hormones.
    Amogastrin
  • HY-108308
    Ibuprofen guaiacol ester
    		Inhibitor 98.49%
    Ibuprofen guaiacol ester (AF 2259; Metoxibutropate) is a potent and orally active prostaglandin synthesis inhibitor. Ibuprofen guaiacol ester has the potential for the research of edema and fever.
    Ibuprofen guaiacol ester
Art. -Nr. Produktname / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

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