Amino Acid Derivatives

Amino Acid Derivatives are bioactive molecules formed through chemical modifications or metabolic transformations of amino acids. They are widely present in living organisms and play crucial roles in physiological, psychological, and athletic performance.
The functions of these derivatives primarily include enhancing energy supply, regulating neurotransmitters, promoting fat metabolism, and reducing muscle damage. For example, creatine can increase muscle strength, enhance ATP resynthesis, and improve short-duration high-intensity exercise performance; tyrosine, as a precursor of dopamine and norepinephrine, helps enhance cognitive function and improve mood, particularly in sleep deprivation conditions, exhibiting anti-fatigue effects; carnitine facilitates fatty acid oxidation in the heart and skeletal muscles, improving endurance performance; HMB (β-hydroxy-β-methylbutyrate) reduces muscle breakdown and promotes muscle mass gain; while taurine exhibits antioxidant and antihypertensive properties and reduces oxidative stress induced by exercise.
Metabolic abnormalities or improper supplementation of amino acid derivatives may be associated with various diseases. For instance, tyrosine metabolism disorders can disrupt neurotransmitter balance, potentially leading to depression or stress-related disorders; elevated ADMA (asymmetric dimethylarginine) levels can inhibit nitric oxide synthesis, increasing the risk of cardiovascular diseases; carnitine deficiency is linked to certain genetic muscle disorders, impairing fat metabolism and energy production. Additionally, HMB may help slow muscle loss under specific conditions, while taurine intake is associated with improved cardiovascular health. Although some of the effects of these derivatives remain debated, they hold significant potential applications in sports nutrition, neurological regulation, and metabolic health.

References:

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. [Content Brief]

Amino Acid Derivatives Related Products (1734):

By Effects:	Inhibitor (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W018849

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dimethylbutanoic acid		99.92%
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dimethylbutanoic acid is a valine derivative.

HY-W141858

N-(3-Indolylacetyl)-L-alanine		99.91%
N-(3-Indolylacetyl)-L-alanine (Indoleacetylalanine) is an indoleacetylamino acid. N-(3-Indolylacetyl)-L-alanine appears to increase callus growth and reduces the ability of growths to differentiate into shoots of Phalaenopsis orchids.

HY-B1732

DL-3-Phenylalanine		99.99%
DL-3-Phenylalanine is a phenylalanine derivative.

HY-W009119

Fmoc-D-Val-OH		99.88%
Fmoc-D-Val-OH is a valine derivative.

HY-I0931

Boc-L-Leu-OH
Boc-L-Leu-OH is a leucine derivative.

HY-116688

2-Hydroxy-4-(methylthio)butyric acid
2-Hydroxy-4-(methylthio)butyric acid (2-Hydroxy-4-(Methylthio)-Butanoic Acid) is an orally active source of methionine. 2-Hydroxy-4-(methylthio)butyric acid reduces the expression of multiple mRNAs (BHMT, MTR, MAT1A, SAHH, and PCK1). 2-Hydroxy-4-(methylthio)butyric acid increases milk production in periparturient cows.

HY-22062

Fmoc-Chg-OH		99.98%
Fmoc-Chg-OH is a Glycine (HY-Y0966) derivative.

HY-79132

N-Fmoc-O-benzyl-L-tyrosine		99.15%
N-Fmoc-O-benzyl-L-tyrosine is a tyrosine derivative.

HY-W016032

Fmoc-3-Ala(3-thienyl)-OH		99.79%
Fmoc-3-Ala(3-thienyl)-OH is an alanine derivative.

HY-W006886

Fmoc-(R)-2-(7-octenyl)Ala-OH		99.43%
Fmoc-(R)-2-(7-octenyl) Ala-OH is an unnatural Fmoc-protected amino acid and modification module. Fmoc-(R)-2-(7-octenyl) Ala-OH serves as a key building block for all-hydrocarbon cross-linking modification of antimicrobial peptides, and facilitates the generation of stapled peptide derivatives. When introduced into specific sites of the parent peptide, Fmoc-(R)-2-(7-octenyl) Ala-OH effectively increases the α-helix content of the peptide chain, thereby significantly enhancing its antimicrobial activity and proteolytic stability. Fmoc-(R)-2-(7-octenyl) Ala-OH is widely used in research on bacterial infections and the development of related antimicrobial agents. Stapled peptide is a specially chemically modified polypeptide. It locks the peptide chain into a stable α-helical structure by introducing a "staple"-like chemical bridge (usually an all-carbon backbone) at specific positions of the peptide chain.

HY-W007750

H-Lys(Z)-OH		99.51%
H-Lys(Z)-OH is a lysine derivative.

HY-W040804

2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid hydrochloride		99.48%
2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid hydrochloride is an alanine derivative.

HY-W014663

(S)-2-((tert-Butoxycarbonyl)amino)-3-hydroxypropanoic acid		99.93%
(S)-2-((tert-Butoxycarbonyl)amino)-3-hydroxypropanoic acid is a serine derivative.

HY-W014259

(S)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid
(S)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a Glycine (HY-Y0966) derivative. (S)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W041867

Boc-Ser-OtBu		98.0%
Boc-Ser-OtBu is a serine derivative.

HY-W129161

Acetyl tetrapeptide-3		98.86%
Acetyl tetrapeptide-3 is a synthetic peptide. Acetyl tetrapeptide-3 enhances the adhesion of hair follicles to the scalp but also promotes the development of new hair follicles. Acetyl tetrapeptide-3 stimulates the synthesis of collagen III in hair follicles. Acetyl tetrapeptide-3 combined with Biochanin A (HY-14595) and ginseng extracts, can stimulate dermal papilla extracellular matrix (ECM) proteins by increasing hydroxyproline, Collagen Type 3, and laminin, yielding a significant improvement in hair follicle size and hair anchoring.

HY-W141949

L-Glutamic acid potassium salt monohydrate		98.0%
L-Glutamic acid potassium salt monohydrate is a glutamic acid derivative.

HY-W041985

Fmoc-D-Allo-Ile-OH		99.90%
Fmoc-D-Allo-Ile-OH is an isoleucine derivative.

HY-W015897

3,4-Dehydro-L-proline		99.43%
3,4-Dehydro-L-proline is aamino acids and their derivatives.

HY-W009502

(tert-Butoxycarbonyl)-L-methionine		99.82%
(tert-Butoxycarbonyl)-L-methionine is a Methionine (HY-13694) derivative.

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