Amino Acid Derivatives

Amino Acid Derivatives are bioactive molecules formed through chemical modifications or metabolic transformations of amino acids. They are widely present in living organisms and play crucial roles in physiological, psychological, and athletic performance.
The functions of these derivatives primarily include enhancing energy supply, regulating neurotransmitters, promoting fat metabolism, and reducing muscle damage. For example, creatine can increase muscle strength, enhance ATP resynthesis, and improve short-duration high-intensity exercise performance; tyrosine, as a precursor of dopamine and norepinephrine, helps enhance cognitive function and improve mood, particularly in sleep deprivation conditions, exhibiting anti-fatigue effects; carnitine facilitates fatty acid oxidation in the heart and skeletal muscles, improving endurance performance; HMB (β-hydroxy-β-methylbutyrate) reduces muscle breakdown and promotes muscle mass gain; while taurine exhibits antioxidant and antihypertensive properties and reduces oxidative stress induced by exercise.
Metabolic abnormalities or improper supplementation of amino acid derivatives may be associated with various diseases. For instance, tyrosine metabolism disorders can disrupt neurotransmitter balance, potentially leading to depression or stress-related disorders; elevated ADMA (asymmetric dimethylarginine) levels can inhibit nitric oxide synthesis, increasing the risk of cardiovascular diseases; carnitine deficiency is linked to certain genetic muscle disorders, impairing fat metabolism and energy production. Additionally, HMB may help slow muscle loss under specific conditions, while taurine intake is associated with improved cardiovascular health. Although some of the effects of these derivatives remain debated, they hold significant potential applications in sports nutrition, neurological regulation, and metabolic health.

References:

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. [Content Brief]

Amino Acid Derivatives Related Products (1735):

By Effects:	Inhibitor (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-23861

N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N5,N5-dimethyl-L-glutamine		99.65%
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N5,N5-dimethyl-L-glutamine is a glutamine derivative.

HY-W010927

Fmoc-Phe(3,5-DiF)-OH		99.21%
Fmoc-Phe(3,5-DiF)-OH is a phenylalanine derivative.

HY-W007743

Boc-Pip-OH		98.81%
Boc-Pip-OH (Boc-L-pipecolic acid) is a t-butyloxycarbonylamino acid. Boc-Pip-OH can serve as a radical precursor.

HY-Y1123

2-Aminoacetamide hydrochloride		99.89%
2-Aminoacetamide hydrochloride (Glycinamide hydrochloride) is a derivative of Glycine (HY-Y0966). 2-Aminoacetamide hydrochloride forms cell-absorbable nanocomplexes with proteins (such as bovine serum albumin) through strong electrostatic interactions, promoting cellular uptake of related proteins. 2-Aminoacetamide hydrochloride synergizes with BMP2 to upregulate the expression of osteogenic marker genes (such as Col1a1, Alp, Runx2) and proteins (such as COL1, BSP), enhancing collagen synthesis. 2-Aminoacetamide hydrochloride synergizes with BMP2 to promote osteoblast differentiation in vitro and bone regeneration in vivo.

HY-W047788

H-Dab(Boc)-OH		98.0%
H-Dab(Boc)-OH is an amino acid derivative with a Boc protecting group, which can be used to synthesize methotrexate (MTX) analogs with antitumor and antifolate activities.

HY-W019028

Fmoc-Lys-OMe.HCl		99.84%
Fmoc-Lys-OMe.HCl is a lysine derivative.

HY-W008379

H-2-Nal-OH		99.9%
H-2-Nal-OH is an alanine derivative.

HY-W013162

Fmoc-4-Pal-OH		99.67%
Fmoc-4-Pal-OH is an alanine derivative.

HY-113014

O-Phospho-L-threonine		99.95%
O-Phospho-L-threonine is a threonine derivative.

HY-W016749

N-Acetyl-DL-aspartic acid		99.93%
N-Acetyl-DL-aspartic acid (Ac-DL-Asp-OH) is an aspartic acid derivative.

HY-W142467

Tetraglycine		98.09%
Tetraglycine is a oligopeptide composed of four glycine monomers.

HY-W050444

Methyl 2-amino-3,3,3-trifluoropropanoate hydrochloride		98.0%
Methyl 2-amino-3,3,3-trifluoropropanoate hydrochloride is an alanine derivative.

HY-W013108

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((tert-butoxycarbonyl)amino)phenyl)propanoic acid		≥98.0%
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((tert-butoxycarbonyl)amino)phenyl)propanoic acid is a phenylalanine derivative.

HY-W011084

Fmoc-L-glutamine		99.15%
Fmoc-L-glutamine is a glutamine derivative.

HY-P2219A

CGGRGD TFA		98.66%
CGGRGD TFA, a RGD derivative with cysteine as its N-terminal.

HY-W724905

gamma-Glutamylisoleucine		99.14%
gamma-Glutamylisoleucine (γ-Glu-Ile; H-γ-Glu-Ile-OH) is a dipeptide composed of γ-glutamic acid and isoleucine, and it is also a degradation product of macromolecular proteins after proteolysis.

HY-34470

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-phenylalanine		99.94%
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-phenylalanine is a phenylalanine derivative.

HY-22002

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-methyl-L-norleucine		99.50%
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-methyl-L-norleucine is a leucine derivative.

HY-W010880

Fmoc-3-Ala(3-benzothienyl)-OH		99.71%
Fmoc-3-Ala(3-benzothienyl)-OH is an alanine derivative.

HY-W013182

(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-aspartic acid		99.57%
(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-aspartic acid is an aspartic acid derivative.

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