Amino Acid Derivatives

Amino Acid Derivatives are bioactive molecules formed through chemical modifications or metabolic transformations of amino acids. They are widely present in living organisms and play crucial roles in physiological, psychological, and athletic performance.
The functions of these derivatives primarily include enhancing energy supply, regulating neurotransmitters, promoting fat metabolism, and reducing muscle damage. For example, creatine can increase muscle strength, enhance ATP resynthesis, and improve short-duration high-intensity exercise performance; tyrosine, as a precursor of dopamine and norepinephrine, helps enhance cognitive function and improve mood, particularly in sleep deprivation conditions, exhibiting anti-fatigue effects; carnitine facilitates fatty acid oxidation in the heart and skeletal muscles, improving endurance performance; HMB (β-hydroxy-β-methylbutyrate) reduces muscle breakdown and promotes muscle mass gain; while taurine exhibits antioxidant and antihypertensive properties and reduces oxidative stress induced by exercise.
Metabolic abnormalities or improper supplementation of amino acid derivatives may be associated with various diseases. For instance, tyrosine metabolism disorders can disrupt neurotransmitter balance, potentially leading to depression or stress-related disorders; elevated ADMA (asymmetric dimethylarginine) levels can inhibit nitric oxide synthesis, increasing the risk of cardiovascular diseases; carnitine deficiency is linked to certain genetic muscle disorders, impairing fat metabolism and energy production. Additionally, HMB may help slow muscle loss under specific conditions, while taurine intake is associated with improved cardiovascular health. Although some of the effects of these derivatives remain debated, they hold significant potential applications in sports nutrition, neurological regulation, and metabolic health.

References:

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. [Content Brief]

Amino Acid Derivatives Related Products (1735):

By Effects:	Inhibitor (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W549438

Cyclo(Phe-Phe)		98.75%
Cyclo(Phe-Phe) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.

HY-W674285

Oxindolylalanine		≥98.0%
Oxindolylalanine, a tryptophan analogue, is an inhibitor of tryptophan indole-lyase (K_i: 5 μM) and tryptophan synthase. Tryptophan indole-lyase is a bacterial enzyme which catalyzes the reversible formation of indole and ammonium pyruvate from L-tryptophan.

HY-159136

Fmoc-Ser(tBu)-OtBu		99.32%
Fmoc-Ser(tBu)-OtBu is a serine derivative.

HY-W009794

3-Fluoro-DL-tyrosine		98.0%
3-Fluoro-DL-tyrosine is a tyrosine derivative.

HY-W011607

L-Alanyl-L-tryptophan		99.04%
L-Alanyl-L-tryptophan is a dipeptide formed from L-alanyl and L-tryptophan, and is also a metabolite. L-Alanyl-L-tryptophan can be adsorbated on the surface of gold nanoparticles, and the Raman signal can be enhanced by SERS technology to obtain the enhanced Raman spectroscopy.

HY-W097355

(R)-2-Amino-3-phenylpropanamide		99.23%
(R)-2-Amino-3-phenylpropanamide (D-Phenylalanine amide) is a non-natural D-α-amino acid derivative and chiral amino acid amide. (R)-2-Amino-3-phenylpropanamide can be converted into D-Phenylalanine (HY-Y0079), which is applicable to the construction of all-D antimicrobial peptides and the synthesis of anti-HIV reagents. (R)-2-Amino-3-phenylpropanamide serves as a reagent for synthesizing benzoxaborole derivative 6, a dual covalent binder of Pseudomonas aeruginosa PBP3. (R)-2-Amino-3-phenylpropanamide is used in colon cancer-related research.

HY-W088805

Fmoc-NIP-OH
Fmoc-NIP-OH (Fmoc-3-carboxypiperidine) is a Fmoc-protected amino acid derivative commonly used in peptide synthesis.

HY-131173

N-Decanoylglycine		99.26%
N-Decanoylglycine is a Glycine (HY-Y0966) derivative.

HY-137950

Fmoc-Asp(OtBu)-Osu		98.0%
Fmoc-Asp(OtBu)-Osu is an aspartic acid derivative.

HY-W089229

N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-carbamimidoyl-L-lysine		99.26%
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-carbamimidoyl-L-lysine is an arginine derivative.

HY-W018620

Diphenylmethylene-glycine benzyl ester		99.01%
Diphenylmethylene-glycine benzyl ester is a Glycine (HY-Y0966) derivative.

HY-Y0555

N-[(Phenylmethoxy)carbonyl]-L-leucine		99.89%
N-[(Phenylmethoxy)carbonyl]-L-leucine is a leucine derivative.

HY-20153

Ethyl 2-(2-(2-(4-chlorophenoxy)phenyl)-N-methylacetamido)acetate		99.03%
Ethyl 2-(2-(2-(4-chlorophenoxy)phenyl)-N-methylacetamido)acetate is a Glycine (HY-Y0966) derivative.

HY-75332

Z-D-Phg-OH
Z-D-Phg-OH (D-Cbz phenylglycine) is a N-blocked amino acids with K_d values of 390 μM and 323 μM for tBuCQN and tBuCQD, respectively.

HY-P10926A

MH42 TFA
MH42 TFA, a peptide, shows high binding to RPE cells.

HY-139078

Furosine dihydrochloride
Furosine dihydrochloride, an amino acid derivative, is an important chemical marker of early-stage Maillard reactions. Furosine dihydrochloride is closely related to a variety of diseases such as diabetes.

HY-W014418

H-D-Val-OtBu.HCl		≥98.0%
H-D-Val-OtBu.HCl is a valine derivative.

HY-W040416

(S)-2-(((Benzyloxy)carbonyl)amino)pent-4-enoic acid
(S)-2-(((Benzyloxy)carbonyl)amino)pent-4-enoic acid is a Glycine (HY-Y0966) derivative.

HY-W009913

2-((Carboxymethyl)amino)benzoic acid		99.93%
2-((Carboxymethyl)amino)benzoic acid is a Glycine (HY-Y0966) derivative.

HY-W091734

Methyl 4-iodo-L-phenylalaninate hydrochloride
Methyl 4-iodo-L-phenylalaninate hydrochloride is a Phenylalaninate derivative. Methyl 4-iodo-L-phenylalaninate hydrochloride can be used for the preparation of factor XI modulators used in the research of thrombotic and thromboembolic. Methyl 4-iodo-L-phenylalaninate hydrochloride can also be used for the synthesis of compounds for the research of amyloid-related diseases, such as Alzheimer’s disease.

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