2. Signaling Pathways
  3. Others
  4. Biochemical Assay Reagents
  5. Biochemical Assay Reagents Activator

Biochemical Assay Reagents Activator

Biochemical Assay Reagents Activator (1):

Cat. No. Product Name Effect Purity
  • HY-178380
    HDAC8-IN-14
    		Activator
    HDAC8-IN-14, a curcuminoid derivative, is a selective HDAC8 inhibitor with a Ki of 9 nM. HDAC8-IN-14 induces the production of reactive oxygen species (ROS), disrupts mitochondrial membrane potential, and promotes apoptosis. HDAC8-IN-14 can significantly promote the accumulation of cells in the sub-G0/G1 phase, consistent with apoptotic or necrotic cell death. HDAC8-IN-14 induces upregulation of cytochrome c, cleaved caspase-3, and the pro-apoptotic protein Bak while leaving the anti-apoptotic Bcl-2 levels unaltered. HDAC8-IN-14 can be used for the study of leukemia.