Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (4)

Isotope-Labeled Compounds Related Products (10876):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-10261AS

Afatinib-d₆ dimaleate
Afatinib-d₆ (dimaleate) is the deuterium labeled Afatinib dimaleate. Afatinib dimaleate is an irreversible EGFR family inhibitor with IC₅₀s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively.

HY-W017406S

L-α-Phenyl-glycine-d₅		98.0%
L-α-Phenyl-glycine-d₅ is the deuterium labeled L-α-Phenyl-glycine.

HY-W724370

Tetraethylammonium bromide-d₂₀
Tetraethylammonium bromide-d₂₀ (TEA bromide-d₂₀) is the deuterium labeled Tetraethylammonium bromide (HY-W014408). Tetraethylammonium bromide is a quaternary ammonium salt consisting of a positively charged tetraethylammonium cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It can also be used as a reagent for the synthesis of various organic compounds, an electrolyte in electrochemical experiments, and a source of tetraethylammonium ions in biochemical and pharmacological research.

HY-B0199AS

Mycophenolate Mofetil-d₄ (hydrochloride)
Mycophenolate Mofetil-d₄ hydrochloride is deuterated labeled Mycophenolate mofetil hydrochloride (HY-B0199A). Mycophenolate mofetil (RS 61443; TM-MMF) hydrochloride is an orally active antimetabolic immunosuppressant with antiproliferative and anti-inflammatory properties. Mycophenolate mofetil hydrochloride significantly inhibits the production of B, T lymphocytes and the proliferation of smooth muscle cells by selectively blocking the de novo purine synthesis pathway. Mycophenolate mofetil hydrochloride effectively reduces adventitial inflammation, medial necrosis and intimal thickening in rat aortic allografts, and decreases the number of lymphocytes expressing the IL-2 receptor, thereby delaying xenograft rejection. Mycophenolate mofetil hydrochloride shows certain toxicity in a hamster-to-rat limb xenotransplantation model when used in combination with FK506 (HY-13756). Mycophenolate mofetil hydrochloride is widely used in studies related to allograft arteriosclerosis (chronic rejection).

HY-N0379S12

D-Mannose-d-1
D-Mannose-d-1 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote.

HY-W015028S

Dimethyl Isophthalate-2,4,5,6-d₄
Dimethyl Isophthalate-2,4,5,6-d₄ is the deuterium labeled Dimethyl isophthalate.

HY-W708886

Methyl-d₃ tetradecanoate
Methyl-d₃ tetradecanoate is the deuterium labeled Methyl myristate (HY-W004288). Methyl myristate is a saturated fatty acid methyl ester obtained from the esterification of myristic acid. Methyl myristate shows a high melanin induction in B16F10 melanoma.

HY-Y1155S

Hexamethylphosphoramide-d₁₈
Hexamethylphosphoramide-d₁₈ is the deuterium labeled Hexamethylphosphoramide (HY-Y1155). Hexamethylphosphoramide is an orally active polar aprotic solvent, flame retardant additive, and carcinogen. Hexamethylphosphoramide undergoes cytochrome P-450-mediated N-demethylation to Formaldehyde. Hexamethylphosphoramide induces DNA-protein crosslinks. Hexamethylphosphoramide has been linked to nasal tumors (squamous cell carcinoma, adenoid squamous cell carcinoma), squamous metaplasia, rhinitis, tracheitis, and reversible and irreversible infertility.

HY-N7092S4

D-Fructose-3-¹³C
D-Fructose-3-¹³C is the ¹³C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.

HY-W074889S

N-Myristoylglycine-d₂
N-Myristoylglycine-d₂ is the deuterium labeled N-Myristoylglycine (HY-W074889). N-Myristoylglycine is a glycine derivative.

HY-113278S

Leucyl-phenylalanine-¹³C₆,¹⁵N TFA
Leucyl-phenylalanine-¹³C₆,¹⁵N TFA is the ¹³C- and ¹⁵N-labeled Leucyl-phenylalanine (HY-113278). Leucyl-phenylalanine belongs to the class of organic compounds known as dipeptides.

HY-16562S2

Irinotecan-¹³C₆
Irinotecan-¹³C₆ ((+)-Irinotecan-¹³C₆) is the ¹³C-labeled Irinotecan (HY-16562). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex.

HY-W701362

Glurate-d₅
Glurate-d₅ (4-Acetylbutyric acid-d₅; 5-Oxohexanoic acid-d₅; NSC-5281-d₅) is the deuterium labeled Glurate (HY-W001957). Glurate (4-Acetylbutyric acid) is an acylating agent. Glurate can be used in the development of antiviral compounds, especially those targeting retroviruses such as herpes virus and HIV. Glurate can be used in the synthesis of acyclic nucleoside derivatives and 5-hydroxyhexanoic acid.

HY-142125S1

7-Hydroxy Granisetron-d₃
7-Hydroxy Granisetron-d₃ is deuterium labeled 7-Hydroxy Granisetron.

HY-12515AS1

Nicardipine-¹³C,d₃ hydrochloride
Nicardipine-¹³C,d₃ hydrochloride (YC-93-¹³C,d₃) is the deuterium and ¹³C-labeled Nicardipine hydrochloride (HY-12515A). Nicardipine hydrochloride (YC-93) is a calcium channel blocker with an IC₅₀ of 1 μM for blocking cardiac calcium channels. Nicardipine hydrochloride acts as an agent for chronic stable angina and for controlling blood pressure.

HY-66011S

rac cis-Moxifloxacin-d₄ hydrochloride		99.78%
rac cis-Moxifloxacin-d₄ (hydrochloride) is the deuterium labeled Moxifloxacin hydrochloride. Moxifloxacin Hydrochloride (BAY 12-8039) is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia.

HY-W585815S

(S)-1-Chloro-3-(hexadecyloxy)propan-2-ol-d₅
(S)-1-Chloro-3-(hexadecyloxy)propan-2-ol-d₅ is a deuterium labeled compound.

HY-W357141S2

MeSA 2-O-b-D-glucoside-d₄
MeSA 2-O-b-D-glucoside-d₄ is the deuterium labeled MeSA 2-O-b-D-glucoside.

HY-16511AS

(E)-Upamostat-d₅
(E)-Upamostat-d₅ ((E)-WX-671-d₅) is the deuterium labeled (E)-Upamostat (HY-16511A). (E)-Upamostat ((E)-WX-671) is an E-isomer of Upamostat (HY-16511). Upamostat (WX-671), a prodrug of WX-UK1, is an orally active serine protease inhibitor.

HY-W749795

N-Boc-Ibrutinib-d₄
N-Boc-Ibrutinib-d₄ is the deuterium labeled (R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate (HY-78859).

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