Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (4)

Isotope-Labeled Compounds Related Products (10876):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W749948

Acephate-d₆
Acephate-d₆ is the deuterium labeled Acephate (HY-B0841). Acephate is a broad-spectrum anticholinesterase insecticide. Acephate acts via inhibiting AChE activity of insects. Acephate is used for control of several species of insects in agriculture and in horticulture.

HY-50898S4

Lapatinib-d₇
Lapatinib-d₇ (GW572016-d₇) is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively.

HY-166478S

O-Desmethyl carvedilol-d₅
O-Desmethyl carvedilol-d₅ (Desmethylcarvedilol-d₅) is deuterium labeled O-Desmethylcarvedilol. O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist Carvedilol (HY-B0006). O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2^R4496C) mutation (IC₅₀ = 7.62 μM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol (HY-B0468) in conscious rabbits (ED₅₀s = 32 and 5 μg/kg, respectively).

HY-W013388S

Crotonaldehyde 2,4-dinitrophenylhydrazone-d₃		99.08%
Crotonaldehyde 2,4-dinitrophenylhydrazone-d₃ is the deuterium labeled Crotonaldehyde 2,4-dinitrophenylhydrazone.

HY-W653975

Bisphenol B-d₈		98.89%
Bisphenol B-d₈ is the deuterium labeled Bisphenol B (HY-W013935). Bisphenol B is a very close structural analog of Bisphenol A (HY-18260), an endocrine disrupting chemical (EDC). Bisphenol B shows endocrine disruptive properties or other adverse effects on animal models.

HY-17359S1

Deferasirox-¹³C₆
Deferasirox-¹³C₆ (ICL 670-¹³C₆) is ¹³C labeled Deferasirox. Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload.

HY-136883S

Benzophenone-9-d₆
Benzophenone-9-d₆ (Disodium 3,3'-carbonylbis[4-hydroxy-6-methoxybenzenesulphonate]-d₆) is deuterium labeled Benzophenone-9.

HY-W014839S1

Cyclamic acid-d₄ sodium
Cyclamic acid-d₄ (Sodium cyclamate-d₄) sodium is the deuterium labeled Cyclamic acid sodium (HY-W014839). Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine.

HY-14649S6

Retinoic acid-d₃-1
Retinoic acid-d₃-1 is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.

HY-41532S

Cyclopropane-carbonyl Chloride-d₅
Cyclopropane-carbonyl Chloride-d₅ is the deuterium labeled Cyclopropanecarboxylic acid chloride.

HY-W010698S

Fmoc-D-Arg(Pbf)-OH-d₆
Fmoc-D-Arg(Pbf)-OH-d₆ is the deuterium labeled Fmoc-D-Arg(Pbf)-OH (HY-W010698). Fmoc-D-Arg(Pbf)-OH is an arginine derivative.

HY-W009815S1

6-Heptyltetrahydro-2H-pyran-2-one-d₄
6-Heptyltetrahydro-2H-pyran-2-one-d₄ is deuterated labeled 6-Heptyltetrahydro-2H-pyran-2-one.

HY-W285163S

1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d₈
1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d₈ is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.

HY-119816S

Piretanide-d₄
Piretanide-d₄ is the deuterium labeled Piretanide. Piretanide is an oral active, relatively safe and effective diuretic. Piretanide has the potential for the research of congestive heart failure with a potential advantage of having potassium-sparing properties. Piretanide can also be used for the research of hypertension[1][2].

HY-W012908S1

DL-Proline-2-d₁		98.0%
DL-Proline-2-d is the deuterium labeled DL-Proline-2.

HY-139593S

Polθ-IN-1-d₃
Polθ-IN-1-d3 (example 1) is a deuterated Polθ inhibitor used for cancer study (extracted from patent WO2021028670).

HY-12388S1

N-Desmethyl clomipramine-d₆
N-Desmethyl clomipramine-d₆ (Desmethylclomipramine-d₆) is deuterium labeled N-Desmethyl clomipramine. Desmethylclomipramine (Norclomipramine) is a metabolite of Clomipramine (HY-B0457A) and can be used for neurological research.

HY-W698686S

β-Galactosyl-C18-ceramide-₃₅
β-Galactosyl-C18-ceramide-d₃5 is deuterium labeled β-Galactosyl-C18-ceramide. β-Galactosyl-C18-ceramide is a bioactive molecule that promotes the regulation of nerve cells, regulates protein kinase C activity, and affects hormone receptors. β-Galactosyl-C18-ceramide is widely used in neuroscience research to explore its effects on nerve cell growth and function. The regulatory function of β-Galactosyl-C18-ceramide makes it a potential application prospect in compound development and disease inhibition.

HY-P3448S1

Certepetide-¹³C₂,¹⁵N
Certepetide-¹³C₂,¹⁵N (CEND-1-¹³C₂,¹⁵N) is the ¹³C- and ¹⁵N-labeled Certepetide (HY-P3448). Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors.

HY-17416S2

Guanfacine-¹³C,d₅ hydrochloride
Guanfacine-¹³C,d₅ hydrochloride is the deuterium and ¹³C labeled Guanfacine hydrochloride (HY-17416). Guanfacine hydrochloride is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD).

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