Platelet-activating Factor Receptor (PAFR)

The platelet-activating factor receptor (PAFR) is a G-protein-coupled receptor involved in both normal physiological and numerous pathophysiological processes. PAFR responds to platelet-activating factor (PAF), a phospholipid mediator of cell-to-cell communication that exhibits diverse physiological effects. Stimulation of the PAFR via binding of platelet-activating factor (PAF) elicits diverse and potent biological activities and plays a profound role in acute inflammation, allergic disorders, endotoxic shock, and anaphylaxis. PAF is a potent and versatile mediator of inflammation that is produced by numerous cell types and tissues, and particularly by leukocytes.

Platelet-activating Factor Receptor (PAFR) Related Products (37):

By Effects:	Inhibitors (3) Agonists (2) Antagonists (11)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-10164

E-6123
E-6123 is a platelet-activating factor (PAF) receptor antagonist.

HY-101833

YM-264
YM-264 is a selective, potent and orally active platelet-activating factor (PAF) antagonist with a pKi value of 8.85 for rabbit platelet membranes.

HY-101675

Setipafant
Setipafant is a platelet-activating factor (PAF) antagonist.

HY-106833A

SDZ-62-434	Antagonist
SDZ-62-434 is a platelet-activating factor (PAF) antagonist. SDZ-62-434 has antiproliferative activity in human solid and haematological malignancies.

HY-118019

Scandenolide
Scandenolide is a sesquiterpene lactone that can be found in Philippines medicinal plant Mikania cordata. Scandenolide inhibits leukotriene and platelet activating factor synthesis in leukocytes.

HY-134101

2-O-Ethyl PAF C-16
2-O-Ethyl PAF C-16 is a homolog of PAF and a competitive ligand for PAF receptor (Platelet-activating Factor Receptor (PAFR)). 2-O-Ethyl PAF C-16 inhibits the binding of the PAF antagonist WEB 2086 (HY-108634) to the PAF receptor with an IC₅₀ of 21 nM.

HY-123399

Ro 19-1400	Antagonist
Ro 19-1400 is a platelet-activating factor antagonist that directly inhibits immunoglobulin E-dependent mediator release.

HY-137257

Carbamyl-PAF	Agonist
Carbamyl-PAF is an analog and agonist of platelet-activating factor (PAF). Carbamyl-PAF is not significantly metabolized by Raji lymphoblasts at 37°C, making it a useful tool for inflammation research. .

HY-N7343

Pregomisin	Antagonist
Pregomisin is a natural compound isolated from the fruits of Schizandra chinensis Baill. Pregomisin showed PAF antagonistic activity and the IC₅₀ values were 48 μM.

HY-N11932

Piperulin A	Inhibitor
Piperulin A is a potent inhibitor of PAFR. Piperulin A inhibits the specific binding of PAFR on isolated rabbit platelet plasma membranes with an IC₅₀ of 7.3 μM.

HY-N3054

Pinusolidic acid	Inhibitor
Pinusolidic acid is a platelet-activating factor (PAF) inhibitor with an IC₅₀ of 23 μM.

HY-N11920

Kadsurenin B	Antagonist
Kadsurenin B is a PAF (platelet-activating factor) antagonist with neuroprotective activity. Kadsurenin B has a wide range of pharmacological research potential, such as antibacterial, anti-inflammatory, neuroprotective, antioxidant, antiplatelet aggregation, cytotoxic, antiparasitic, etc.

HY-101594

Tulopafant
Tulopafant is a platelet activating factor (PAF) antagonist.

HY-19097

Ro-24-4736
Ro 24-4736 is a potent, selective, p.o.-active platelet-activating factor (PAF) antagonist with a long duration of action. Ro-24-4736 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-19084

Ro-24-0238
Ro-24-0238 is an antagonist of platelet activating factor (PAF) and inhibitor of thromboxane synthesis, used for lessening the inflammation and damage resulting from a local release of PAF.

HY-100153

48740 RP
48740 RP (RP-55778) is a platelet-activating factor (PAF) antagonist.

HY-U00040

PAF-AN-1
PAF-AN-1 is a platelet activating factor receptor (PAF) antagonist.

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