2. Signaling Pathways
  3. PROTAC
  4. SNIPERs

SNIPERs

IAP-dependent Protein Eraser, Specific and Nongenetic inhibitor of apoptosis protein [IAP]-dependent Protein Erasers

SNIPERs

Related Products

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Specific and Non-genetic inhibitor of apoptosis protein [IAP]-dependent Protein Erasers (SNIPER), a class of small-molecule degraders, is designed to induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins.

SNIPERs recruit IAP family of RING-type E3 ligases-cIAP1, cIAP2, and XIAP. The SNIPER chemical structure consists of selective IAP antagonist (i.e., Bestatin, MV1, and LCL161), PEG linker and peptide- or small-molecule-based protein of interest (POI)-specific component. Unlike the chimeric molecules that recruit von Hippel-Lindau and cereblon ubiquitin ligases, SNIPERs induce simultaneous degradation of IAPs such as cIAP1 and XIAP along with the target proteins.

SNIPERs Related Products (29):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-111854
    SNIPER(ABL)-015
    SNIPER(ABL)-015, conjugating GNF5 (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 5 μM .
    SNIPER(ABL)-015
  • HY-111851
    SNIPER(ABL)-049
    SNIPER(ABL)-049, conjugating Imatinib (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 100 μM.
    SNIPER(ABL)-049
  • HY-111878
    BzNH-BS 2443928-42-3
    BzNH-BS contains two different ligands, methyl-bestatin (MeBS) for cIAP1 and benzoyl-amide, which are connected by linkers. MeBS as a ligand for cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase.
    BzNH-BS
  • HY-111841
    PROTAC CRABP-II Degrader-2 1225383-38-9
    PROTAC CRABP-II Degrader-2 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on IAP ligand.
    PROTAC CRABP-II Degrader-2
  • HY-111876A
    SNIPER(TACC3)-1 hydrochloride
    SNIPERTACC3-1 hydrochloride targets the TACC3 protein for degradation via the ubiquitin-proteasome pathway based on IAP ligand. SNIPERTACC3-1 hydrochloride induces cancer cell death.
    SNIPER(TACC3)-1 hydrochloride
  • HY-111879
    Biotin-BS
    Biotin-BS contains two different ligands, methyl-bestatin (MeBS) for cIAP1 and biotin, which are connected by linkers. MeBS as a ligand for cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase.
    Biotin-BS
  • HY-111863
    SNIPER(ABL)-047
    SNIPER(ABL)-047, conjugating HG-7-85-01 (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 2 μM.
    SNIPER(ABL)-047
  • HY-111877A
    SNIPER(TACC3)-2 hydrochloride
    SNIPER(TACC3)-2 hydrochloride targets the TACC3 protein for degradation via the ubiquitin-proteasome pathway based on IAP ligand. SNIPER(TACC3)-2 hydrochloride induces cancer cell death.
    SNIPER(TACC3)-2 hydrochloride
  • HY-111874
    SNIPER(ABL)-039 2222354-29-0
    SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively.
    SNIPER(ABL)-039