1. PROTAC
    Protein Tyrosine Kinase/RTK
  2. SNIPER
    Bcr-Abl
  3. SNIPER(ABL)-039

SNIPER(ABL)-039 

Cat. No.: HY-111874
Handling Instructions

SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively.

For research use only. We do not sell to patients.

SNIPER(ABL)-039 Chemical Structure

SNIPER(ABL)-039 Chemical Structure

CAS No. : 2222354-29-0

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Description

SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively[1].

IC50 & Target[1]

Abl

0.54 nM (IC50)

cIAP1

10 nM (IC50)

cIAP2

12 nM (IC50)

XIAP

50 nM (IC50)

SNIPER

 

Abl

10 nM (DC50)

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

1114.77

Formula

C₅₄H₆₈ClN₁₁O₉S₂

CAS No.

2222354-29-0

SMILES

CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(C(COCCOCCOCCOC5=CC(C(C6=CSC([[email protected]]7N(C([[email protected]](C8CCCCC8)NC([[email protected]](C)NC)=O)=O)CCC7)=N6)=O)=CC=C5)=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
SNIPER(ABL)-039
Cat. No.:
HY-111874
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SNIPER(ABL)-039

Cat. No.: HY-111874