SNIPER(ABL)-039
SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2222354-29-0
- Formula: C54H68ClN11O9S2
- Molecular Weight:1114.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Abl 0.54 nM (IC50) |
cIAP1 10 nM (IC50) |
cIAP2 12 nM (IC50) |
XIAP 50 nM (IC50) |
SNIPER |
Abl 10 nM (DC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | DC50 |
>=3 nM
Compound: 4; SNIPER(ABL)-39
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Protac activity at BCR-ABL/XIAP in human K562 cells assessed as induction of ABL protein degradation after 6 hrs by Western blot analysis
Protac activity at BCR-ABL/XIAP in human K562 cells assessed as induction of ABL protein degradation after 6 hrs by Western blot analysis
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[PMID: 31047748] |
Chemical Information
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CAS No. 2222354-29-0
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Molecular Weight 1114.77
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Formula C54H68ClN11O9S2
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SMILES
CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(C(COCCOCCOCCOC5=CC(C(C6=CSC([C@H]7N(C([C@H](C8CCCCC8)NC([C@H](C)NC)=O)=O)CCC7)=N6)=O)=CC=C5)=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SNIPER(ABL)-039 Related Classifications
HY-111874 Related Classifications
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