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Cat. No.: HY-111841

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PROTAC CRABP-II Degrader-2

PROTAC CRABP-II Degrader-2 is a cellular retinoic acid-binding protein (CRABP-II) SNIPER degrader. PROTAC CRABP-II Degrader-2 hijacks the cIAP1 E3 ligase to induce ubiquitination and proteasomal degradation of CRABP-II. PROTAC CRABP-II Degrader-2 can be used for the research of neuroblastoma.
(Pink: CRABP-II ligand (HY-14649); Blue: IAP ligand (HY-B0134); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 1225383-38-9
Formula: C₄₄H₆₄N₄O₁₀
Molecular Weight:809.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

PROTAC CRABP-II Degrader-2 Chemical Structure

CAS No.: 1225383-38-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC CRABP-II Degrader-2 is a cellular retinoic acid-binding protein (CRABP-II) SNIPER degrader. PROTAC CRABP-II Degrader-2 hijacks the cIAP1 E3 ligase to induce ubiquitination and proteasomal degradation of CRABP-II. PROTAC CRABP-II Degrader-2 can be used for the research of neuroblastoma^[1]. (Pink: CRABP-II ligand (HY-14649); Blue: IAP ligand (HY-B0134); Black: linker).

IC₅₀ & Target

SNIPER, PROTAC^[1].

In Vitro

PROTAC CRABP-II Degrader-2 (Table 3, Compound 2; n = 2) at 10 μM induces CRABP-II degradation in IMR-32 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1225383-38-9
Molecular Weight 809.00
Formula C₄₄H₆₄N₄O₁₀
SMILES

CC(/C=C/C=C(/C=C/C1=C(/C(CCC(C)1C)=N/OCC(NCCOCCOCCOC([C@H](CC(C)C)NC([C@@H](O)[C@H](N)CC2=CC=CC=C2)=O)=O)=O)C)C)=C\C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Computational and structural biotechnology journal. 2019;17:160-176. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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