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  2. SNIPER
    Estrogen Receptor/ERR
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  3. PROTAC ERα Degrader-2

PROTAC ERα Degrader-2 

Cat. No.: HY-111846
Handling Instructions

PROTAC ERα Degrader-2 comprises a cIAP1 ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 μM concentration in human mammary tumor MCF7 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs).

For research use only. We do not sell to patients.

PROTAC ERα Degrader-2 Chemical Structure

PROTAC ERα Degrader-2 Chemical Structure

CAS No. : 1351169-29-3

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Description

PROTAC ERα Degrader-2 comprises a cIAP1 ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 μM concentration in human mammary tumor MCF7 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 220 mg/mL (287.97 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3090 mL 6.5448 mL 13.0897 mL
5 mM 0.2618 mL 1.3090 mL 2.6179 mL
10 mM 0.1309 mL 0.6545 mL 1.3090 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

763.96

Formula

C₄₂H₆₁N₅O₈

CAS No.

1351169-29-3

SMILES

C[[email protected]@]12[[email protected]](CC/C2=N\OCC(NCCOCCOCCNC([[email protected]](CC(C)C)NC([[email protected]@H](O)[[email protected]](N)CC3=CC=CC=C3)=O)=O)=O)([H])[[email protected]@]4([H])[[email protected]](C5=CC=C(O)C=C5CC4)([H])CC1

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
PROTAC ERα Degrader-2
Cat. No.:
HY-111846
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PROTAC ERα Degrader-2

Cat. No.: HY-111846