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  3. PROTAC ERα Degrader-2

PROTAC ERα Degrader-2 

Cat. No.: HY-111846 Purity: 98.02%
Handling Instructions

PROTAC ERα Degrader-2 comprises a cIAP1 ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 μM concentration in human mammary tumor MCF7 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs).

For research use only. We do not sell to patients.

PROTAC ERα Degrader-2 Chemical Structure

PROTAC ERα Degrader-2 Chemical Structure

CAS No. : 1351169-29-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 714 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2850 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

PROTAC ERα Degrader-2 comprises a cIAP1 ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 μM concentration in human mammary tumor MCF7 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].

IC50 & Target

ERα

 

cIAP1

 

Molecular Weight

763.96

Formula

C₄₂H₆₁N₅O₈

CAS No.

1351169-29-3

SMILES

C[[email protected]@]12[[email protected]](CC/C2=N\OCC(NCCOCCOCCNC([[email protected]](CC(C)C)NC([[email protected]@H](O)[[email protected]](N)CC3=CC=CC=C3)=O)=O)=O)([H])[[email protected]@]4([H])[[email protected]](C5=CC=C(O)C=C5CC4)([H])CC1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (261.79 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3090 mL 6.5448 mL 13.0897 mL
5 mM 0.2618 mL 1.3090 mL 2.6179 mL
10 mM 0.1309 mL 0.6545 mL 1.3090 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (6.54 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (6.54 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
PROTAC ERα Degrader-2
Cat. No.:
HY-111846
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