1. PROTAC
  2. PROTAC Linker
  3. Bis-NH2-PEG2

Bis-NH2-PEG2 (Synonyms: PROTAC Linker 19)

Cat. No.: HY-128833 Purity: >98.0%
Handling Instructions

Bis-NH2-PEG2 (PROTAC Linker 19) is a PROTAC linker, which refers to the PEG composition. Bis-NH2-PEG2 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

For research use only. We do not sell to patients.

Bis-NH2-PEG2 Chemical Structure

Bis-NH2-PEG2 Chemical Structure

CAS No. : 929-59-9

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Description

Bis-NH2-PEG2 (PROTAC Linker 19) is a PROTAC linker, which refers to the PEG composition. Bis-NH2-PEG2 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC50 & Target[1]

PEGs

 

Molecular Weight

148.20

Formula

C₆H₁₆N₂O₂

CAS No.

929-59-9

SMILES

NCCOCCOCCN

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1686.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7476 mL 33.7382 mL 67.4764 mL
5 mM 1.3495 mL 6.7476 mL 13.4953 mL
10 mM 0.6748 mL 3.3738 mL 6.7476 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (14.04 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (14.04 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (14.04 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Bis-NH2-PEG2
Cat. No.:
HY-128833
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