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  3. PROTAC BET degrader-2

PROTAC BET degrader-2 

Cat. No.: HY-114228 Purity: 98.21%
Handling Instructions

PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.

For research use only. We do not sell to patients.

PROTAC BET degrader-2 Chemical Structure

PROTAC BET degrader-2 Chemical Structure

CAS No. : 2093388-33-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 721 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1850 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

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  • Biological Activity

  • Technical Information

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  • References

Description

PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.

IC50 & Target

IC50: 9.6 nM (BET in the RS4;11 leukemia cell line)[1].

In Vitro

PROTAC BET degrader-2 (compound 25) is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (64.86 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2973 mL 6.4864 mL 12.9729 mL
5 mM 0.2595 mL 1.2973 mL 2.5946 mL
10 mM 0.1297 mL 0.6486 mL 1.2973 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.83 mg/mL (1.08 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

770.84

Formula

C₄₁H₄₂N₁₀O₆

CAS No.

2093388-33-9

SMILES

O=C(C1=NC(NC2=CC(C3CC3)=NN2CC)=C4C(NC5=C4C=C(OC)C(C6=C(C)ON=C6C)=C5)=N1)NCCCC7=CC=CC8=C7CN(C(CC9)C(NC9=O)=O)C8=O

Shipping

Room temperature in continental US; may vary elsewhere

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
PROTAC BET degrader-2
Cat. No.:
HY-114228
Quantity:

PROTAC BET degrader-2

Cat. No.: HY-114228