2. PROTAC
    Vitamin D Related/Nuclear Receptor
    Metabolic Enzyme/Protease
  3. SNIPERs
    PROTACs
    RAR/RXR
  4. PROTAC RAR Degrader-1

PROTAC RAR Degrader-1 

Cat. No.: HY-111844 Purity: 95.07%
COA Handling Instructions

PROTAC RAR Degrader-1 comprises a IAP ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs).

For research use only. We do not sell to patients.

PROTAC RAR Degrader-1 Chemical Structure

PROTAC RAR Degrader-1 Chemical Structure

CAS No. : 1351169-27-1

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1 mg USD 550 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC RAR Degrader-1 comprises a IAP ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].

IC50 & Target

cIAP1

 

Molecular Weight

917.14

Appearance

Solid

Formula

C51H72N4O11
CAS No.
SMILES

O=C(O)C1=CC=C(/C=C/C(C2=CC(C(C)(C)C)=CC(C(C)(C)C)=C2)=O)C=C1OCCCNC(COCCOCCOCCNC([[email protected]](CC(C)C)NC([[email protected]@H](O)[[email protected]](N)CC3=CC=CC=C3)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro: 

DMSO : ≥ 80 mg/mL (87.23 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0903 mL 5.4517 mL 10.9035 mL
5 mM 0.2181 mL 1.0903 mL 2.1807 mL
10 mM 0.1090 mL 0.5452 mL 1.0903 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2 mg/mL (2.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2 mg/mL (2.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (2.18 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 95.07%

COA (242 KB) HNMR (266 KB) LCMS (100 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PROTAC RAR Degrader-11351169-27-1PROTAC RAR Degrader1PROTAC RAR Degrader 1SNIPERsPROTACsRAR/RXRIAP-dependent Protein Eraser, Specific and Nongenetic inhibitor of apoptosis protein [IAP]-dependent Protein ErasersRetinoic acid receptorsRetinoid X receptorsInhibitorinhibitorinhibit

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