1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Zofenopril

Zofenopril 

Cat. No.: HY-108321 Purity: 98.81%
Handling Instructions

Zofenopril is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 81 μM.

For research use only. We do not sell to patients.

Zofenopril Chemical Structure

Zofenopril Chemical Structure

CAS No. : 81872-10-8

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Description

Zofenopril is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 81 μM.

IC50 & Target

IC50: 81 μM (ACE)[1]

In Vitro

Kinetic analyses demonstrate that enalapril inhibits the uptake of GlySar in a competitive manner (Ki approximately 6 mM). Fosinopril and Zofenopril have the greatest inhibitory potency (IC50 values of 55 and 81μM, respectively) while the other ACE inhibitors exhibit low-affinity interactions with the renal peptide transporter[1].

In Vivo

Zofenopril, a sulphydrylic compound, at doses higher than 70 mg/kg i.p. produces significant protection (i.e. at 70 mg/kg, P=0.044, F=2.17, d.f.=18; at higher concentration P<0.05) against the tonic phase of the audiogenic seizure response. Pretreatment with Zofenopril (15 mg/kg, i.p.) is able to produce a consistent shift to the left of the dose-response curves and a significant reduction of ED50 values against clonus of some AEDs with the exceptions of diazepam, felbamate, phenobarbital and phenytoin compare with concurrent groups, suggesting an increase in anticonvulsant activity[2].

Clinical Trial
Molecular Weight

429.55

Formula

C₂₂H₂₃NO₄S₂

CAS No.

81872-10-8

SMILES

O=C(O)[[email protected]]1N(C([[email protected]](C)CSC(C2=CC=CC=C2)=O)=O)C[[email protected]@H](SC3=CC=CC=C3)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (11.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3280 mL 11.6401 mL 23.2802 mL
5 mM 0.4656 mL 2.3280 mL 4.6560 mL
10 mM 0.2328 mL 1.1640 mL 2.3280 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

Studies are performed in rabbit renal brush border membrane vesicles in which the uptake of radiolabeled GlySar is examined in the absence and presence of captopril, enalapril, enalaprilat, fosinopril, lisinopril, quinapril, quinaprilat, ramipril and Zofenopril[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[2]

Male and female mice weighing 8 to12 g (22 to 26 days old) or 20 to 28 g (48 to 56 days old) are used. Mice are exposed to auditory stimulation, 45, 60 or 120 min following intraperitoneal (i.p.) administration of ACE inhibitors (including Zofenopril) (10 to 100 mg/kg) or vehicle and 45 min following i.p. injection of the AEDs studied. All ACE inhibitors are suspended in a 1% solution of Tween 80 before administration[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

ZofenoprilAngiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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