2. Immunology/Inflammation
  3. Aryl Hydrocarbon Receptor
  4. BAY 2416964

BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment.

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CAS 番号 : 2242464-44-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 104 在庫あり
Solution
10 mM * 1 mL in DMSO USD 104 在庫あり
Solid
1 mg $50 在庫あり
5 mg $95 在庫あり
10 mg $150 在庫あり
25 mg $300 在庫あり
50 mg $450 在庫あり
100 mg $720 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 1 publication(s) in Google Scholar

BAY 2416964 関連抗体

Top Publications Citing Use of Products
Cell Proliferation/Viability Assay
RT-PCR
WB

    BAY 2416964 purchased from MedChemExpress. Usage Cited in: Cell Oncol (Dordr). 2025 Dec 23;49(1):3.  [Abstract]

    IC50 of Py8119 or Py230 cells treated with 10 nM FICZ, 1 µM 5F-203, 1 µM tapinarof, or 1 µM BAY2416964 in combination with 0.01 to 1000 nM RBN2397, n = 8. RBN2397 treatment alone from Fig. 4C is added for comparison.

    BAY 2416964 purchased from MedChemExpress. Usage Cited in: Cell Oncol (Dordr). 2025 Dec 23;49(1):3.  [Abstract]

    IC50 curve of Py230 and Py8119 cells treated with fixed concentration of 10 µg/mL DMXAA and 1 µM BAY2416964 with 0.01 to 1000 nM RBN2397.

    BAY 2416964 purchased from MedChemExpress. Usage Cited in: Cell Oncol (Dordr). 2025 Dec 23;49(1):3.  [Abstract]

    Fosl1 mRNA levels in Py230 cells treated for 48 h with DMSO, 10 µg/ml DMXAA, 100 nM RBN2397 and 1 µM BAY2416964 alone or in combination or DMSO treated Py8119 cells.

    BAY 2416964 purchased from MedChemExpress. Usage Cited in: Cell Oncol (Dordr). 2025 Dec 23;49(1):3.  [Abstract]

    Western blot of Py230 cells treated DMSO, 10 µg/ml DMXAA, 100 nM RBN2397 and 1 µM BAY2416964 alone or in combination for 72 h. 30 µg protein loaded. Representative image of n = 2.

    • 生物活性

    • 純度とドキュメンテーション

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    製品説明

    BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment[1].

    IC50 & Target

    IC50: 341 nM (Aryl hydrocarbon receptor (AHR))[1]
    体外実験

    BAY 2416964 (Example 192) induces AHR-regulated gene CYP1A1 expression in a human monocytic U937 cells with an IC50 of 4.3 nM[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    BAY 2416964 関連抗体
    分子量

    387.82

    分子式

    C18H18ClN5O3
    CAS 番号
    Appearance

    Solid

    Color

    Light yellow to green yellow

    SMILES

    O=C(C1=CC(C2=CC=C(Cl)C=C2)=NN(C3=CN(C)N=C3)C1=O)N[C@@H](C)CO
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 50 mg/mL (128.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5785 mL 12.8926 mL 25.7852 mL
    5 mM 0.5157 mL 2.5785 mL 5.1570 mL
    10 mM 0.2579 mL 1.2893 mL 2.5785 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    • Dilution Calculator

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

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    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.5 mg/mL (6.45 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.59%

    COA (249 KB) HNMR (263 KB) LCMS (95 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.5785 mL 12.8926 mL 25.7852 mL 64.4629 mL
    5 mM 0.5157 mL 2.5785 mL 5.1570 mL 12.8926 mL
    10 mM 0.2579 mL 1.2893 mL 2.5785 mL 6.4463 mL
    15 mM 0.1719 mL 0.8595 mL 1.7190 mL 4.2975 mL
    20 mM 0.1289 mL 0.6446 mL 1.2893 mL 3.2231 mL
    25 mM 0.1031 mL 0.5157 mL 1.0314 mL 2.5785 mL
    30 mM 0.0860 mL 0.4298 mL 0.8595 mL 2.1488 mL
    40 mM 0.0645 mL 0.3223 mL 0.6446 mL 1.6116 mL
    50 mM 0.0516 mL 0.2579 mL 0.5157 mL 1.2893 mL
    60 mM 0.0430 mL 0.2149 mL 0.4298 mL 1.0744 mL
    80 mM 0.0322 mL 0.1612 mL 0.3223 mL 0.8058 mL
    100 mM 0.0258 mL 0.1289 mL 0.2579 mL 0.6446 mL
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    BAY 2416964 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    BAY 24169642242464-44-2BAY2416964BAY-2416964Aryl Hydrocarbon ReceptorAhR2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamideAHRanti-cancerCYP1A1Inhibitorinhibitorinhibit

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    製品名:
    BAY 2416964
    製品番号:
    HY-135829
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