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  4. Akuammine

Akuammine is an indole alkaloid that has been found in Picralima nitida and has analgesic activity. It selectively binds to the μ- and κ-opioid receptors over the δ-opioid receptor (Kis=0.3, 1.68, and 10.4 μM for the human receptors, respectively). Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC50s=2.6 and 0.073 μM, respectively). It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg.

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Akuammine

Akuammine Estructura química

No. CAS : 3512-87-6

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1 mg Obtener un presupuesto 2 - 3 weeks 4 - 5 weeks 5 - 6 weeks 1 - 2 weeks
5 mg Obtener un presupuesto 2 - 3 weeks 4 - 5 weeks 5 - 6 weeks 1 - 2 weeks
10 mg   Obtener un presupuesto  
50 mg   Obtener un presupuesto  
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Akuammine Related Antibodies

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Descripciòn

Akuammine is an indole alkaloid that has been found in Picralima nitida and has analgesic activity. It selectively binds to the μ- and κ-opioid receptors over the δ-opioid receptor (Kis=0.3, 1.68, and 10.4 μM for the human receptors, respectively). Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC50s=2.6 and 0.073 μM, respectively). It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg.

Peso molecular

382.45

Fòrmula

C22H26N2O4
No. CAS
SMILES

C/C=C(C1)\[C@H]2[C@]3(C(OC)=O)CO[C@@]45N(C)C6=CC=C(O)C=C6[C@]43CCN1[C@H]5C2
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Room temperature in continental US; may vary elsewhere.
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Akuammine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Akuammine3512-87-6(-)-Akuammine VincamajoridineOthersInhibitorinhibitorinhibit

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Nombre del producto:
Akuammine
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HY-122189
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