Alpha-lipoic acid choline ester chloride (Synonyms: EV 06 chloride; UNR 844 chloride)

製品番号: HY-134633 純度: 99.72%: Data Sheet SDS COA 取扱説明書
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Alpha-lipoic acid choline ester (EV 06) chloride is choline ester of alpha-lipoic acid. Alpha-lipoic acid choline ester chloride reduces the disulfide bond level of lens proteins. Alpha-lipoic acid choline ester chloride improves lens elasticity. Alpha-lipoic acid choline ester chloride is hydrolyzed by ocular esterases to release alpha-lipoic acid and choline. Alpha-lipoic acid choline ester chloride is used for the research of presbyopia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Alpha-lipoic acid choline ester chloride 構造式

CAS 番号 : 1808266-58-1

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 49	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 49	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$45	在庫あり	Estimated Time of Arrival: December 31
10 mg	$70	在庫あり	Estimated Time of Arrival: December 31
25 mg	$140	在庫あり	Estimated Time of Arrival: December 31
50 mg	$225	在庫あり	Estimated Time of Arrival: December 31
100 mg	$360	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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純度とドキュメンテーション
参考文献
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製品説明

体内実験

Alpha-lipoic acid choline ester chloride (5%; topical ocular; three times per day; 5 weeks) increases the lens elasticity of aged mice to a level exceeding that of young mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J (8-month-old)^[1]
Dosage:	5% (formulated ophthalmic solution), 2.5 μL drop
Administration:	topical ocular; three times per day; 5 weeks
Result:	Exhibited increased elasticity compared to untreated contralateral eyes, with lower relative force required for equivalent Z displacements. Was more elastic than lenses from 8-week-old (young) control mice in most cases. Showed no significant crossover effect in untreated left eyes of treated mice.

分子量

327.93

分子式

C₁₃H₂₆ClNO₂S₂

CAS 番号

1808266-58-1

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(OCC[N+](C)(C)C)CCCC[C@H]1SSCC1.[Cl-]

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (304.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0494 mL	15.2472 mL	30.4943 mL
5 mM	0.6099 mL	3.0494 mL	6.0989 mL
10 mM	0.3049 mL	1.5247 mL	3.0494 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.72%

Select Batch:

データシート (269 KB) SDS (597 KB)

COA (244 KB) HNMR (269 KB) RP-HPLC (242 KB) MS (69 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Garner WH, et al. Protein Disulfide Levels and Lens Elasticity Modulation: Applications for Presbyopia. Invest Ophthalmol Vis Sci. 2016;57(6):2851-2863. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0494 mL	15.2472 mL	30.4943 mL	76.2358 mL
	5 mM	0.6099 mL	3.0494 mL	6.0989 mL	15.2472 mL
	10 mM	0.3049 mL	1.5247 mL	3.0494 mL	7.6236 mL
	15 mM	0.2033 mL	1.0165 mL	2.0330 mL	5.0824 mL
	20 mM	0.1525 mL	0.7624 mL	1.5247 mL	3.8118 mL
	25 mM	0.1220 mL	0.6099 mL	1.2198 mL	3.0494 mL
	30 mM	0.1016 mL	0.5082 mL	1.0165 mL	2.5412 mL
	40 mM	0.0762 mL	0.3812 mL	0.7624 mL	1.9059 mL
	50 mM	0.0610 mL	0.3049 mL	0.6099 mL	1.5247 mL
	60 mM	0.0508 mL	0.2541 mL	0.5082 mL	1.2706 mL
	80 mM	0.0381 mL	0.1906 mL	0.3812 mL	0.9529 mL
	100 mM	0.0305 mL	0.1525 mL	0.3049 mL	0.7624 mL

Alpha-lipoic acid choline ester chloride Related Classifications

Neurological Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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