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  4. Alpha-lipoic acid choline ester chloride

Alpha-lipoic acid choline ester chloride  (Synonyms: EV 06 chloride; UNR 844 chloride)

Cat. No.: HY-134633 Purity: 99.72%
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Handling Instructions Technical Support

Alpha-lipoic acid choline ester (EV 06) chloride is choline ester of alpha-lipoic acid. Alpha-lipoic acid choline ester chloride reduces the disulfide bond level of lens proteins. Alpha-lipoic acid choline ester chloride improves lens elasticity. Alpha-lipoic acid choline ester chloride is hydrolyzed by ocular esterases to release alpha-lipoic acid and choline. Alpha-lipoic acid choline ester chloride is used for the research of presbyopia.

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Alpha-lipoic acid choline ester chloride

Alpha-lipoic acid choline ester chloride 화학구조

CAS No. : 1808266-58-1

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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Alpha-lipoic acid choline ester chloride Related Antibodies

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제품 설명

Alpha-lipoic acid choline ester (EV 06) chloride is choline ester of alpha-lipoic acid. Alpha-lipoic acid choline ester chloride reduces the disulfide bond level of lens proteins. Alpha-lipoic acid choline ester chloride improves lens elasticity. Alpha-lipoic acid choline ester chloride is hydrolyzed by ocular esterases to release alpha-lipoic acid and choline. Alpha-lipoic acid choline ester chloride is used for the research of presbyopia[1].

In Vivo

Alpha-lipoic acid choline ester chloride (5%; topical ocular; three times per day; 5 weeks) increases the lens elasticity of aged mice to a level exceeding that of young mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (8-month-old)[1]
Dosage: 5% (formulated ophthalmic solution), 2.5 μL drop
Administration: topical ocular; three times per day; 5 weeks
Result: Exhibited increased elasticity compared to untreated contralateral eyes, with lower relative force required for equivalent Z displacements.
Was more elastic than lenses from 8-week-old (young) control mice in most cases.
Showed no significant crossover effect in untreated left eyes of treated mice.
분자량

327.93

화학식

C13H26ClNO2S2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(OCC[N+](C)(C)C)CCCC[C@H]1SSCC1.[Cl-]
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도
In Vitro: 

DMSO : 100 mg/mL (304.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0494 mL 15.2472 mL 30.4943 mL
5 mM 0.6099 mL 3.0494 mL 6.0989 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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(per animal)

g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0494 mL 15.2472 mL 30.4943 mL 76.2358 mL
5 mM 0.6099 mL 3.0494 mL 6.0989 mL 15.2472 mL
10 mM 0.3049 mL 1.5247 mL 3.0494 mL 7.6236 mL
15 mM 0.2033 mL 1.0165 mL 2.0330 mL 5.0824 mL
20 mM 0.1525 mL 0.7624 mL 1.5247 mL 3.8118 mL
25 mM 0.1220 mL 0.6099 mL 1.2198 mL 3.0494 mL
30 mM 0.1016 mL 0.5082 mL 1.0165 mL 2.5412 mL
40 mM 0.0762 mL 0.3812 mL 0.7624 mL 1.9059 mL
50 mM 0.0610 mL 0.3049 mL 0.6099 mL 1.5247 mL
60 mM 0.0508 mL 0.2541 mL 0.5082 mL 1.2706 mL
80 mM 0.0381 mL 0.1906 mL 0.3812 mL 0.9529 mL
100 mM 0.0305 mL 0.1525 mL 0.3049 mL 0.7624 mL
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Alpha-lipoic acid choline ester chloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alpha-lipoic acid choline ester1808266-58-1EV 06UNR 844EV06EV-06UNR844UNR-844Drug IntermediateDrug Iintermediatecholinelens protein disulfideyoung micelipoic acidaqueous humoraged micepresbyopiaocular esterasesInhibitorinhibitorinhibit

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상품명:
Alpha-lipoic acid choline ester chloride
Cat. No.:
HY-134633
수량:
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