ABCC5 Antibody (YA7785)(PBS only)

Cat. No.: HY-P88101A: Data Sheet User Guide for Antibodies
FAQs
Technical Support

ABCC5 Antibody (YA7785) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ABCC5.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

ABCC5 Antibody (YA7785) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ABCC5.

Host

Mouse

Molecular Weight

Predicted band size: 23.5 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

O15440

Immunogen

Full length human recombinant protein of human ABCC5 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro) (PubMed:10893247, PubMed:12637526, PubMed:12695538, PubMed:15899835, PubMed:17229149, PubMed:25964343). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins (PubMed:26515061). Confers resistance to the antiviral agent PMEA (PubMed:12695538). Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated (PubMed:10840050, PubMed:12435799, PubMed:12695538, PubMed:15899835). Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561). May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (By similarity)

Subcellular Localization：Basolateral cell membrane,Golgi apparatus lumen,Endosome membrane,Cytoplasmic granule,Apical cell membrane

Expression：
Tissue_Specificity: Predominant isoform in retinal pigment epithelium, bladder, and stomach|Ubiquitously expressed, but levels in brain and muscle are especially high (PubMed:10438534, PubMed:15501592, PubMed:9827529). All isoforms are equally expressed in retina (PubMed:17521428)

Isoforms & Post-Translational Modification：O15440 has 5 isomers: O15440-1: 160660 Da (predicted); O15440-2: 25341 Da (predicted); O15440-3: 23988 Da (predicted); O15440-4: 23677 Da (predicted); O15440-5: 155732 Da (predicted).

Synonyms

ABC33; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP

Documentation

User Guide for Antibodies (1077 KB)