AZI2 Antibody (YA2226)(PBS only)

Cat. No.: HY-P82481A: Ficha de datos User Guide for Antibodies
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AZI2 Antibody (YA2226) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AZI2.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn
Referencias

Descripciòn

AZI2 Antibody (YA2226) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AZI2.

Host

Rabbit

Peso molecular

Predicted band size: 45 kDa;

Observed band size: 45 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Rat

SwissProt ID

Q9H6S1

Gene ID

113451 [NCBI]

Immunogen

Recombinant protein of human AZI2

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000

Pureza	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (PubMed:14560022, PubMed:21931631). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (PubMed:14560022, PubMed:21931631). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (PubMed:14560022, PubMed:21931631). Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B (PubMed:14560022, PubMed:21931631). Participates in IFNB promoter activation via TICAM1 (PubMed:15611223)

Subcellular Localization：Cytoplasm

Expression：
Tissue_specificity:Widely expressed (PubMed:14560022) . Abundant expression seen in the pancreas and testis (PubMed:14560022)

Isoforms & Post-Translational Modification：Q9H6S1 has 4 isomers: Q9H6S1-1: 44935 Da (predicted); Q9H6S1-3: 26510 Da (predicted); Q9H6S1-4: 28188 Da (predicted); Q9H6S1-5: 26921 Da (predicted).
Ubiquitinated via 'Lys-48'-linked polyubiquitination by TRIM38, leading to its degradation

Subunit：Homodimer (By similarity). Interacts with IKBKE (PubMed:14560022, PubMed:17568778). Interacts with TBK1 (PubMed:14560022, PubMed:21931631, PubMed:29251827). Interacts with TICAM1 (PubMed:15611223).

Research Field

Signal Transduction

Synonyms

AZ2; NAP1; TILP

Documentación

User Guide for Antibodies (1077 KB)

Referencias

[1]. /biology-dictionary/a549-cell.html [Content Brief]