BDH2 Antibody (YA8099)(PBS only)

Cat. No.: HY-P88415A: Data Sheet User Guide for Antibodies
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BDH2 Antibody (YA8099) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to BDH2.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

BDH2 Antibody (YA8099) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to BDH2.

Host

Mouse

Molecular Weight

Predicted band size: 26.5 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9BUT1

Immunogen

Full length human recombinant protein of human BDH2 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-500
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250
FC FC: Flow Cytometry	1:100

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (By similarity) (PubMed:35150746). Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines (PubMed:35150746). Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (By similarity). May act as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372)

Subcellular Localization：Cytoplasm

Expression：
Tissue_Specificity: Detected in liver (at protein level)
Induction: Induced by low iron levels, and down-regulated by elevated iron levels

Isoforms & Post-Translational Modification：Q9BUT1 has three isomers: Q9BUT1-1: 26724 Da (predicted); Q9BUT1-2: 19209 Da (predicted); Q9BUT1-3: 15626 Da (predicted).

Subunit：Homotetramer

Synonyms

DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR; UNQ6308

Documentation

User Guide for Antibodies (1077 KB)