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Cat. No.: HY-P85987

CD45 Antibody (YA5679)

Name: CD45 Antibody (YA5679)
Brand: MedChemExpress
SKU: HY-P85987
Availability: PreOrder

CD45 Antibody (YA5679) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD45.

For research use only. We do not sell to patients.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	IHC-P IHC-P: Immunohistochemistry-Paraffin	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:200-400	1:500-5000

Description

CD45 Antibody (YA5679) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD45.

Host Mouse
Clonality Monoclonal
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 200 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Immunogen

Synthesized peptide derived from human CD45 (LCA) AA range: 500-600

Purification

affinity chromatography.

Conjugation

Non-conjugated

Isotype

IgG2b

Appearance

Liquid
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

CD45 (PTPRC/LCA) is a receptor-type protein tyrosine phosphatase common to all white blood cells and is the most classic pan-marker of immune cells. CD45 can be used to label hematopoietic cells, regulate TCR, BCR, and NK cell activation signals, and control immune cell development, differentiation, and function.
Subcellular Localization

Cell membrane, Synapse
Expression

Tissue_specificity:Isomer 1: Detected in thymocytes. Isomer 2: Detected in thymocytes. Isomer 3: Detected in thymocytes. Isomer 4: Not detected in thymocytes. Isomer 5: Detected in thymocytes. Isomer 6: Not detected in thymocytes. Isomer 7: Detected in thymocytes. Isomer 8: Not detected in thymocytes.
Isoforms & Post-Translational Modification

CD45 has 8 isomers: P08575-3: 147486 Da (predicted); P08575-4: 131130 Da (predicted); P08575-5: 142623 Da (predicted); P08575-6: 142898 Da (predicted); P08575-7: 140582 Da (predicted); P08575-8: 138034 Da (predicted); P08575-9: 135719 Da (predicted); P08575-10: 135993 Da (predicted).
Heavily N- and O-glycosylated
Subunit

Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes
SwissProt ID

P08575-3
Gene ID

5788 [NCBI]