CHRNA2 Antibody (YA4300)

Art. -Nr.: HY-P84603: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

CHRNA2 Antibody (YA4300) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHRNA2.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Größe	Verfügbarkeit	Menge
20 μL	Auf Lager	Estimated Time of Arrival: December 31
50 μL	Auf Lager	Estimated Time of Arrival: December 31
100 μL	Auf Lager	Estimated Time of Arrival: December 31
250 μL	Angebot einholen

or Massenanfrage

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung

Beschreibung

CHRNA2 Antibody (YA4300) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHRNA2.

Host

Mouse

Clonality

Monoclonal Antibody

Molekulargewicht

Predicted band size: 60 kDa;

Observed band size: 60 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Rat

SwissProt ID

Q15822

Gene ID

1135 [NCBI]

Immunogen

Purified recombinant fragment of human CHRNA2 (AA: extra 27-264) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Reinheit	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:18723036). CHRNA2 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4 and plays a role in nicotine dependence (PubMed:24467848, PubMed:27493220)

Subcellular Localization：Synaptic cell membrane; Multi-pass membrane protein; Cell membrane; Multi-pass membrane protein

Subunit：Neuronal AChR is composed of two different types of subunits: alpha and non-alpha (beta). CHRNA2/alpha-2 subunit can be combined to CHRNB2/beta-2 or CHRNB4/beta-4 to give rise to functional receptors. Both CHRNA2:CHRNB2 and CHRNA2:CHRNB4 nAChR complexes are heteropentamers with two subtypes: LS (low agonist sensitivity) with a (CHRNA2)3:(CHRNB2/4)2 and HS (high agonist sensitivity) with a (CHRNA2)2:(CHRNB2/4)3 stoichiometries; the subtypes differ in their subunit binding interfaces which are involved in ligand binding

Dokumentation

Select Batch:

Data Sheet (234 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)