Cytokeratin 17 Antibody (YA5681)

Art. -Nr.: HY-P85989: Data Sheet User Guide for Antibodies
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Cytokeratin 17 Antibody (YA5681) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cytokeratin 17.

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100 μL		Angebot einholen

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung
Verweise

Beschreibung

Cytokeratin 17 Antibody (YA5681) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cytokeratin 17.

Host

Mouse

Clonality

Monoclonal

Molekulargewicht

Predicted band size: 48 kDa;

Observed band size: 48 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q04695

Gene ID

3872 [NCBI]

Immunogen

Synthesized peptide derived from human Cytokeratin 17 AA range: 300-432

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:500-5000

Reinheit	affinity chromatography.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation

Subcellular Localization：Cytoplasm

Expression：
Tissue_specificity:This protein is expressed in the outer root sheath and medulla of hair follicles (especially in eyebrows and beards) , fingertips, nail matrix and nail bed epithelium, stratified squamous epithelium of the mucosa, basal cells of the oral epithelium, palmar and plantar epithelium, sweat glands, and mammary glands. Furthermore, it is also expressed in the myoepithelial cells of the prostate, basal layer of the bladder, sebaceous gland cambium cells, and the adventitia of the cervix (protein level) .

Induction:Induced in damaged or stressed epidermis. Induced by the cytokines interferon-gamma (IFN-gamma) , tumor necrosis factor alpha (TNF-alpha) and transforming growth factor-alpha (TGF-alpha) , and by the potent NF-kappa B inhibitor compounds Bay 11-7082 and Bay 11-7085. Down-regulated by the drug Imatinib

Subunit：Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers (KRT6A or KRT6B).

Dokumentation

User Guide for Antibodies (1077 KB)

Verweise

[1]. /biology-dictionary/sum-159-pt-cell.html [Content Brief]